نتایج جستجو برای: nuclear factor kappa b

تعداد نتایج: 1828688  

Journal: :Birth Defects Research Part A: Clinical and Molecular Teratology 2014

Journal: :The Journal of Experimental Medicine 1991
N Mackman K Brand T S Edgington

Lipopolysaccharide (LPS) activation of cells of monocytic lineage leads to rapid and transient expression of a set of inflammatory gene products, including tissue factor (TF). This transmembrane receptor is the major cellular initiator of the blood coagulation cascades, and induced expression of TF is postulated to play a role in inflammation. Functional studies using transfected THP-1 monocyti...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Simos Simeonidis Ignazio Castagliuolo Amy Pan Jennifer Liu Chi-Chi Wang Andreas Mykoniatis Asia Pasha Leyla Valenick Stavros Sougioultzis Dezheng Zhao Charalabos Pothoulakis

We report here that human monocytic/macrophage THP-1 cells express the neurokinin 1 receptor (NK-1R), and that exposure of these cells to the proinflammatory cytokine IL-1 beta increased the expression of the NK-1R gene at the mRNA and protein levels. Because IL-1 beta function involves nuclear factor kappa B (NF-kappa B) activation, these data suggest that this increase in the expression of th...

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