Aldose reductase gene polymorphisms has been indicated to be associated with diabetic retinopathy (DR). The research data were from PubMed and EMBASE. We identified -106C > T single nucleotide polymorphism (SNP). Pool odds ratio (OR) 95% CI calculated. Nine studies included. ALR2 106C was the increased risk of DR in T1DM (C vs. T, OR = 2.07, p 0.001; CC CT + TT, 2.56, 0.005). allele TT genot...

The results of molecular genetic analysis 13 polymorphic variants genes, according to the data genome-wide association studies (GWAS) associated with development addictive states, in group persons alcohol dependence (n = 142) and comparison 211) are presented. main genotyping method is polymerase chain reaction (PCR) followed by high resolution melting (HRM) clustering profiles; validated using...

Nonalcoholic fatty liver disease (NAFLD) is an obesity-associated disease and dysregulation of adipokines has an important role in its development. Omentin-1 (ITLN1 protein) and resistin are two adipokine secreted from adipose tissue. Single nucleotide polymorphisms in the adipokine genes may affect expression and activity of the adipokine, and thus play a contributory role in NAFLD pathogenesi...

Background: Recurrent pregnancy loss (RPL), that affects 1-5% of couples, is a multifactorial disorder as both genetic and environmental factors are involved. The aim of this study was to determine association of single nucleotide polymorphisms (SNPs) located on estrogen receptor beta (ERβ) gene with the risk of RPL in a population of Iranian women; +1082G>A (rs1256049) in exon 5, +1730G>A (rs4...

Background: Metformin is an insulin sensitizing drug, which is co-administered with Clominophene citrate or gonadotropins in most cases of polycystic ovary syndrome (PCOS), to improve ovulation. STK11 gene is necessary for action of metformin. Therefore the study of STK11 polymorphisms is important as pharmacogenetics aspects of metformin. The aim of our study was to investigate polymorphism of...

Inflammatory bowel disease (IBD) applies to two main forms of chronic relapsing inflammatory intestinal disorders: Crohn's (CD), Ulcerative colitis (UC). CD requires an irregular immune reaction that induces intense inflammation. The cause is not yet fully known; previous research, however, indicated inflammation the intestines elevated or continues due inappropriate responses associations betw...

Background: Tumor necrosis factor (TNF) is a cytokine that includes different types of molecules participate in cellular and organic responses, Single Nucleotide Polymorphisms (SNPs) TNF are associated to the pathogenesis chronic inflammatory diseases local or systemic autoimmune diseases. Objective: To know prevalence TNFα (G238A G308A) LTα (A252G) polymorphisms population Mexican women with p...

The rapid developments in high-throughput sequencing technologies have allowed researchers to analyze the full genomic sequence of organisms faster and cheaper than ever before. An important application such advancements is identify impact single nucleotide polymorphisms (SNPs) on phenotypes genotypes same species by discovering factors that affect occurrence SNPs. focus this study determine wh...

Diatoms belonging to the family Epithemiaceae have endosymbiont ‘spheroid bodies’, which received attention as a model provide new insights into early stages of organelle evolution. Uniparental inheritance, known in wide range sexually reproducing eukaryotes, is considered be one key characteristics acquired during evolution an organelle. However, there has been no information about inheritance...

The vitamin D receptor (VDR) gene is a candidate gene for susceptibility to autoimmune disorders. Association studies of VDR polymorphisms and risk of type 1 diabetes often produced conflicting results in different ethnic backgrounds. The aim of this study was to test for association between common VDR polymorphisms and the genetic susceptibility to type 1 diabetes in the Portuguese population....