Anaplastic large-cell lymphoma (ALCL) was initially recognized on the basis of morphologic features and the consistent expression of CD30. It then became evident that the majority of these tumors are derived from lymphoid cells of T or null immunophenotype. The subsequent finding that t(2;5)(p23;q35) occurs in 40% to 60% of ALCL patients established a distinct clinicopathologic entity. This chr...

The Ink4a-Arf locus, which encodes two distinct tumor suppressor proteins, is inactivated in many cancers. Whereas p16Ink4a is an inhibitor of cyclin D-dependent kinases, p19Arf (p14ARF in humans) antagonizes the E3 ubiquitin protein ligase activity of Mdm2 to activate p53. We now recognize that Arf functions in both p53-dependent and -independent modes to counteract hyper-proliferative signals...

ABSTRACT This study concerns an eigenvalue problem of a vibro-acoustic coupling system. In the conventional method, the dynamics of a vibro-acoustic coupling system is calculated with modal coupling methodology which uses eigenfunctions of a rigid-walled cavity. Therefore, particle velocity on the surface of a panel is always calculated as zero, while it should be coincident with the velocity o...

Fundamental understanding of the goaf gas distribution in a gassy coal mine is necessary for developing effective goaf gas drainage strategies in the longwall coal mine. The goaf gas was subjected to the surface and body forces that were classified depending upon whether they acted on the surface area or the volume of the gas element. Of these forces, the body forces were more predominant in di...

BACKGROUND NPM, TFF3 and TACC1 are molecular markers that play important roles in cell differentiation. Herein, we investigated their prognostic impact in patients with primary gastric cancer (GC) and determined whether they could be used as markers of more aggressive gastric carcinomas by detecting the extent of expression in human gastric carcinoma samples. METHODOLOGY/PRINCIPAL FINDINGS Tu...

Factor VIII circulates in noncovalent complex with von Willebrand factor (vWf). The topography of this complex was evaluated by fluorescence energy transfer using factor VIII subunits modified with N-(1-pyrenyl)maleimide (NPM; fluorescence donor) and vWf-derived fragments modified with 7-diethylamino-3-[4'-maleimidylphenyl]-4-methyl coumarin (CPM; fluorescence acceptor). Results from a previous...

Non-parametric and semi-parametric analysis of panel count data have recently been an active research topic in statistical literature. Maximum likelihood method based on non-homogeneous Poisson process has been proved an efficient inference procedure for such analysis. However, computing the nonand semi-parametric maximum likelihood estimates (MLE) can be very intensive numerically. In this man...

BACKGROUND Rodent models for urban air pollution show consistent induction of inflammatory responses in major brain regions. However, the initial impact of air pollution particulate material on olfactory gateways has not been reported. OBJECTIVE We evaluated the olfactory neuroepithelium (OE) and brain regional responses to a nanosized subfraction of urban traffic ultrafine particulate matter...

Serving as the cellular factory for the biogenesis of ribosomes (the molecular machines responsible for the decoding of mRNAs to proteins), the nucleolus controls a vast array of physiological processes including cell growth and proliferation. It thus comes as no surprise that inherited and acquired abnormalities in ribosome biogenesis can lead to tumorigenesis and that changes in size and numb...

Phosphorylation-specific antibodies provide a powerful tool for analysing the regulation and activity of proteins in the MAP (mitogen-activated protein) kinase and other signalling pathways. Using synchronized cells, it was observed that phosphorylation-specific antibodies developed against the active form of MKK1/MKK2 (MAP kinase kinase-1 and -2) reacted with a protein that was approx. 35 kDa ...