With the availability of newer and more potent immunosuppressive agents, post-transplant survival has markedly improved. However, these agents, together with the rising age of transplant recipients, have been associated with a rise in the incidence of new-onset diabetes after transplantation (NODAT). Besides the traditional risk factors for diabetes mellitus, such as age, obesity, hypertension,...

PURPOSE Published data on the weight loss effects of glucagon-like peptide 1 (GLP-1) receptor agonists are reviewed, with a focus on data from clinical trials. SUMMARY Obesity is a significant health problem in the United States (an estimated 69% of U.S. adults are overweight and nearly 35% are obese), and few drugs have proven safety and efficacy as adjuncts to lifestyle modification for wei...

Background: Polycystic Ovary Syndrome (PCOS) is the commonest cause of anovulatory infertility. Treatment modes available are numerous. The use of anti-obesity medications such as orlistat or insulin sensitizing agents such as metformin is sometimes indicated in these patients. We aimed to compare the effect of metformin vs orlistat on the hormone, lipid profile &ovulation status in obese PCOS ...

Introduction Diets and exercise should be the mainstay of management of obesity. Nonetheless, many people put their faith in slimming agents as a quick fix for weight reduction. Their effectiveness appears to be limited as the amount of weight loss is small. The lack of long-term safety data and the occurrence of adverse effects are important consideration. Proprietary slimming products are het...

This retrospective observational study investigated the prevalence of obesity in persons with type 2 diabetes, trends in obesity resulting from the duration and treatment of diabetes, and treatment-related changes in HbA1c and body mass index (BMI). Data on 1773 type 2 diabetics (802 men and 971 women) were obtained from the CroDiabNET registry. Follow-up included the analysis of patients' age,...

The ideal anti-obesity drug would produce sustained weight loss with minimal side effects. The mechanisms that regulate energy balance have substantial built-in redundancy, overlap considerably with other physiological functions, and are influenced by social, hedonic and psychological factors that limit the effectiveness of pharmacological interventions. It is therefore unsurprising that anti-o...

the markedly high prevalence of obesity contributes to the increased incidence of chronic diseases, such as diabetes, hypertension, sleep apnea, and heart disease. because of high prevalence of obesity in almost all countries, it has been the focus of many researches throughout the world during the recent decades. along with increasing researches, new concepts and controversies have been emerge...

Background: Infantile obesity is becoming increasingly recognized as one of the public health problems in Iran. Objective: Obesity charts of a cohort of 317 healthy infants and their parents living in Shiraz (Southern Iran) are presented and the familial pattern of infants’ obesity with that of its parents explored. Methods: An adjusted weight-for-height index was used to develop power type obe...

Abstract Introduction Stevens-Johnson Syndrome(SJS),toxic epidermal necrolysis(TEN), and SJS/TEN Overlap Syndrome are on the same spectrum of severe blistering skin diseases affecting mucosal surfaces body.They have an immunological etiology caused by toxins, drugs, or infectious agents. The mortality rate for patients with these conditions ishigh, but there is limited research outcomes those a...

Obesity is a major public health problem. For many obese patients, diet and exercise are an inadequate treatment and bariatric surgery may be too extreme of a treatment. As with many other chronic diseases, pharmacologic treatment may be an attractive option for selected obese patients. Antiobesity drugs may potentially work through one of three mechanisms: (1) appetite suppression, (2) interfe...