Ocular inflammations are common diseases that may lead to serious vision-threatening obstacles. Eye drops for antiinflammation therapy need to be administered multiple times daily at a high dosage due to the rapid precorneal removal and low bioavailability of drugs. To overcome these problems, a cRGD-functionalized DSPE-PEG2000 nanomicelle (DSPE-PEG2000-cRGD) encapsulated with flurbiprofen is p...

INTRODUCTION Ocular targeted therapy has enormously been advanced by implementation of new methods of drug delivery and targeting using implantable drug delivery systems (DDSs) or devices (DDDs), stimuli-responsive advanced biomaterials, multimodal nanomedicines, cell therapy modalities and medical bioMEMs. These technologies tackle several ocular diseases such as inflammation-based diseases (e...

The eye presents unique opportunities and challenges when it comes to the delivery of Pharmaceuticals. While absorption by this route is bungling, there are few side effects with conventional ocular dosage forms like eye drops and eye suspensions. Several polymeric systems have been used to fabricate ocular inserts for better ocular bioavailability and retention of drug for which gelling system...

The third Annual ARVO/Pfizer Ophthalmic Research Institute Conference was held Friday and Saturday, May 4 and 5, 2007 at the Fort Lauderdale Grande Hotel and Yacht Club, Fort Lauderdale, Florida. The conference, funded by the ARVO Foundation for Eye Research through a grant from Pfizer Ophthalmics, provided an opportunity to gather experts from within and outside ophthalmology to develop strate...

Inflammation is a complex biological response and like other parts of the body, ocular inflammation could have untoward effects on vision if not detected and/or diagnosed early. NSAIDs are the major ocular therapeutics for treating such eye inflammations and preferred over corticosteroids. NSAIDs are given orally as well as topically to treat ocular inflammations, however topical route is prefe...

Non-aqueous system are well known as solvent or drug suspension vehicles and oleogels micro emulsion with no aqueous phase (anhydrous, non-aqueous oil-in-oil emulsion) have had relatively scant attention yet may have uses as drug reservoir as well as template for the preparation of microemulsion combination with a cosurfactant. Microemulsions have emerged as novel vehicles for drug delivery whi...

In recent years, ophthalmic drug delivery has been recognised as having some of the most significantly unmet packaging and delivery needs of any injectable drug market segment. Ocular injections often require very small, precise dose volumes to be administered in a smooth, controlled manner to a precise location in the eye without the introduction of air bubbles or foreign particulate matter su...

Ocular drug delivery is an interesting field in current research. Silica nanoparticles (SiNPs) are promising drug carriers for ophthalmic drug delivery. However, little is known about the toxicity of SiNPs on ocular surface cells such as human corneal epithelial cells (HCECs). In this study, we evaluated the cytotoxicity induced by 50, 100 and 150 nm sizes of SiNPs on cultured HCECs for up to 4...