PURPOSE We recently demonstrated that molecular therapy using aminoglycosides can overcome the underlying genetic defect in two zebrafish models of ocular coloboma and showed abnormal cell death to be a key feature associated with the optic fissure closure defects. In further studies to identify molecular therapies for this common congenital malformation, we now examine the effects of anti-apop...

OBJECTIVE to analyze ocular survival in eyes with uveal melanoma treated with conservative therapies, in a centre that applies all treatment modalities. METHODS Patients diagnosed with uveal melanoma and treated between September 1990 and April 2007 were included in an historical cohorts study. RESULTS 273 patients were included. 193 were treated with conservative treatments (70.69%) and 80...

purpose: to determine the prevalence of ocular manifestations in marfan’s syndrome. methods: this cross-sectional study was performed on 43 patients referred to ophthalmology clinics of yazd medical university over 27 months. common ocular manifestations of marfan’s syndrome including lens dislocation, corneal disorders, retinal conditions, glaucoma were evaluated. results: the study included 2...

PURPOSE To compare the clinical results of cultivated oral mucosal epithelial cell sheet transplantation (COMET) of substrate-free sheets with those of COMET of amniotic membrane (AM)-based sheets. METHODS Sixteen eyes receiving COMET of substrate-free sheets (substrate-free group) were studied retrospectively and compared with disease-, age-, and ocular surface status-matched eyes undergoing...

background: behcet syndrome is a recurrent inflammatory disorder that frequently involves the ocular system. the purpose of this study was to determine the frequency of ocular involvement in cases of behcet's disease in babol, north of iran. methods: from april 2003 to december 2009, 100 cases of behcet's disease who were admitted at the department of ophthalmology and internal medici...

AIMS Three issues were investigated in adult outpatients with orbital metastases. One, how accurate are current diagnostic methods? Two, what is the survival associated with orbital metastases? Three, did any clinical factors correlate with prognosis in this patient cohort? METHODS Retrospective analysis of patients with orbital metastases managed in an ocular oncology unit. RESULTS 11 of 3...

PURPOSE To compare the effectiveness of immunization with "naked" DNA corresponding to the genes encoding five HSV-1 glycoproteins, gB, gC, gD, gE, and gI (5gP DNA), with immunization with the five glycoproteins (5gP protein). Also, to compare immunization of 5gP protein in Montanide ISA 720 (SEPPIC, Paris, France), an adjuvant recently approved for use in humans, with immunization of 5gP prote...

There are no satisfactory treatment options for patients with ocular melanoma metastatic to liver, and after liver metastases are identified, median survival is only between 2 and 7 months. Because liver metastases are the sole or life-limiting component of disease in the vast majority of patients who recur, we reasoned that complete vascular isolation and perfusion of the liver might result in...

purpose : to review current knowledge about ocular effects of sulfur mustard (sm) and the associated histopathologic findings and clinical manifestations methods : literature review of medical articles (human and animal studies) was accomplished using pubmed, scopus and isi databases. a total of 274 relevant articles in english were retrieved and reviewed thoroughly. results : eyes are the most...

 Background: Behçet’s disease (BD) is a multi-system inflammatory vascular disorder with auto immunity background. It is a genetic disease that may be affected by environmental factors. Behçet’s disease may involve different organs like urogenital, skin, eyes and gastrointestinal system. According to geographic area and genetic predisposition, prevalence of the disease is different. The aim of...