OBJECT Accurate localization of the subthalamic nucleus (STN) is important for proper placement of the electrodes in deep brain stimulation (DBS) surgery for patients with advanced Parkinson disease. The authors evaluated the accuracy of our modified composite targeting method and the value of using high-field MR imaging for targeting the STN. METHODS Thirteen patients with advanced Parkinson...

in descriptive statistics, there are two computational algorithms for determining the variance s2, of a set of observations : algorithm 1: s2= - , algorithm 2: s2= , where . it is interesting to discuss, which of the above formulas is numerically more trustworthy in machine numbers sets. i this paper, based on total effect of rounding error, we prove that the second algorithm is better than ...

in reinforced concrete design, there are situations where transfer of shear across a specific plane needs to be considered. examples of such situation include corbels, bearing shoes, ledger beam bearing, and a host of connection between precast concrete elements. in this study, the shear transfer behavior of reinforced concrete is investigated experimentally by conducting test on 6 precracked p...

conclusions ma is nowadays the most accurate stereotactic anatomic guide for targeting the human na. it is a representative example of how stereotactic microanatomy could serve the development of stereotactic microneurosurgery. following the currently used trajectory through the alic, a dbs electrode placement within the na, targeting the ma, is feasible, allowing either na or alic stimulation....

in the open-pit mining, one of the first decisions that must be made in production planning stage, after completing the design of final pit limits, is determining of the processing plant cut-off grade. since this grade has an essential effect on operations, choosing the optimum cut-off grade is of considerable importance. different goals may be used for determining optimum cut-off grade. one of...

Prior research shows that micronutrients, particularly amino acids, can assist individuals with substance dependence to quit various drugs of abuse, including cannabis, alcohol, and cocaine. As part of a wider investigation of the impact of micronutrients (mostly vitamins and minerals) on psychiatric symptoms, such as Attention-Deficit/Hyperactivity Disorder (ADHD), depression, and anxiety, we ...

CRISPR/Cas9 systems are a versatile tool for genome editing due to the highly efficient targeting of DNA sequences complementary to their RNA guide strands. However, it has been shown that RNA-guided Cas9 nuclease cleaves genomic DNA sequences containing mismatches to the guide strand. A better understanding of the CRISPR/Cas9 specificity is needed to minimize off-target cleavage in large mamma...

CRISPR/Cas9 has demonstrated a high-efficiency in site-specific gene targeting. However, potential off-target effects of the Cas9 nuclease represent a major safety concern for any therapeutic application. Here, we knock out the Tafazzin gene by CRISPR/Cas9 in human-induced pluripotent stem cells with 54% efficiency. We combine whole-genome sequencing and deep-targeted sequencing to characterise...

The paper analyzes the evidence regarding freight road pricing, complements it with game theoretic analyses, and concludes that moving trucks to the off-peak hours require comprehensive policies targeting key components of the supply chain (i.e., receivers and carriers). The paper shows that a request from receivers asking carriers to do off-peak deliveries is likely to have an impact across th...

A new approach for Quartz Enhanced Photoacoustic Spectroscopy is presented, based on an acoustic excitation from the outside of prongs a quartz tuning fork, to increase sensitivity sensor. For this purpose, we introduce monolithic double-resonator (double-mR) in T-shape configuration, using 3D printing. It was modelized and experimentally characterized 1392 nm distributed feedback laser diode, ...