Vesicular stomatitis virus (VSV) exhibits a remarkably robust and pantropic infectivity, mediated by its coat protein, VSV-G. Using this property, recombinant forms of VSV and VSV-G-pseudotyped viral vectors are being developed for gene therapy, vaccination, and viral oncolysis and are extensively used for gene transduction in vivo and in vitro. The broad tropism of VSV suggests that it enters ...

Patients with stage IV gastric cancer suffer from dismal outcomes, a challenge especially in many Asian populations and for which new therapeutic options are needed. To explore this issue, we used oncolytic reovirus combination currently chemotherapeutic drugs (irinotecan, paclitaxel, docetaxel) the treatment of other gastrointestinal cells vitro mouse model. Cell viability was quantified by WS...

Newcastle disease virus (NDV) exhibits oncolysis in its natural form. This oncolytic (OV) has the potential to specifically infect, propagate, and lyse cancer cells while sparing normal cells. study was aimed screen for NDV strain isolated from poultry. A total of ten velogenic strains were propagated 10 day old embryonated SPF chicken eggs allantoic fluid these infected collected further study...