نتایج جستجو برای: oncolytic viruses

تعداد نتایج: 102002  

Journal: :Journal of Clinical Investigation 2018

Journal: :Journal of Clinical Practice 2015

2012
Zulkifli Mustafa Hidayah Roslan Jafri Malin Abdullah

Cancer now is well described as a genetically defective disease that causes the overgrowth of particular cells. Cancer is phenotypically related to multiple sequential gene mutation and amplification, genetic translocalization, preservation of telomeres and loss of tumor suppressor gene that lead to immortal cell (Sinkovics & Horvath, 2000). In this regard, gliomas are particularly defined as p...

Journal: :Expert Review of Anticancer Therapy 2008

2018
Biljana Petrovic Valerio Leoni Valentina Gatta Anna Zaghini Andrea Vannini Gabriella Campadelli-Fiume

Oncolytic viruses gain cancer specificity in several ways. Like the majority of viruses, they grow better in cancer cells that are defective in mounting the host response to viruses. Often, they are attenuated by deletion or mutation of virulence genes that counteract the host response or are naturally occurring oncolytic mutants. In contrast, retargeted viruses are not attenuated or deleted; t...

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