ultrastructural changes in immature articular carilage were studied after treatment of 5-weeks-old rats with ofloxacin, a fluoroquinolone, and in magnesium deficiency.we concluded that quinolone-induced arthropathy is probably due to chelation of functionally available magnesium in joint cartilage as magnesium deficiency in joint cartilage could impair chondrocyte-matrix- interaction which is m...

background: cryptosporidiosis is a zoonotic disease with public health importance, especially for individuals with weak immune system, such as children, elderly people and immune suppressed ones. evaluation of the prevalence of cryptosporidium in wild rodents such as wild brown rats could help to establish an epidemiological map of cryptosporidiosis. the aim of the current study was to assess t...

sub chronic exposure to lead in rats slows gastric emptying, but little is known about the effects of lead on gastric secretion. this study was designed to investigate the effects of lead on gastric acid secretion and its possible mechanisms in rats. lead acetate was dissolved in drinking water in a concentration of 1%. sodium acetate-containing water with a molar concentration similar to lead ...

the aim of this animal study was to evaluate the possible effects of carbonated soft drink consumption on the rate of orthodontic tooth movement in rats.thirty-six adult male sprague-dawley rats were randomly divided into two experimental groups and one control group. in the experimental groups (a&b;), the water in the dietary regimen was replaced with soft drinks (fanta® in group a and cola® i...

background: data shows vanadium protects pancreatic beta cells (bc) from diabetic animals. whether this effect is direct or through the relief of glucose toxicity is not clear. this study evaluated the potential effect of oral vanadyl sulfate (vanadium) on glycemic status and pancreatic bc of normal and diabetic rats. methods: rats were divided into five groups of normal and diabetic. diabetes ...

introduction: hypercholesterolemia is a metabolic disorder that ultimately results in arterial sclerosis and complications like hypertension and coronary arterial diseases. various drugs have been used for the treatment of this condition and many studies are underway for introducing new drugs. chitosan and salvadora persica are two such drugs. chitosan is produced by deacetylation of chitin whi...

background: tramadol narcotic drugs or epoxied artificial categories is weaker than morphine and stronger than ibuprofen and acetaminophen drug. the aim of this study was to investigate the effect of oral tramadol on some liver enzymes in the rat. materials and methods: in this study, 60 male wistar rats were randomized into three groups (one control group, and experimental groups of 1, and 2)....

objective(s) arsenic compounds are potent human carcinogen and produce a variety of stress responses in mammalian cells. recently sodium arsenite has been recommended to be used as anti malignancy drug by american food and drug administration (fda). in this study, we aimed to determine the apoptosis inducing effect of sodium arsenite on rat bone marrow mesenchymal stem cells exposed in vitro. m...

results the results reveal that pq can decrease mitochondrial viability, deplete gsh content, increase mitochondrial ros formation, and enhance lpo and mitochondrial membrane damage. the pretreatment of mitochondria with ng has the ability to reduce the toxic effects of pq in isolated mitochondria. background paraquat (pq) is a dipyridyl herbicide that sustains damage due to redox cycling. an i...

Aims: Chemical toxicity is one of the major leading causes tissues injuries, which impair tissue’s ability to maintain normal physiological functions. Pterocarpus erinaceus a medicinal plant use as traditional remedy for treatment several disorders associated with injuries. This study therefore aimed at investigating protective efficiency leaves extract in carbon-tetrachloride-induced hepatic a...