Cholesterol has been implicated in the pathogenesis of late-onset Alzheimer's disease (LOAD) and the cholesteryl ester transfer protein (CETP) is critical to cholesterol regulation within the cell, making CETP an Alzheimer's disease candidate gene. Several studies have suggested that CETP I405V (rs5882) is associated with cognitive function and LOAD risk, but findings vary and most studies have...

Cholesterol has been implicated in the pathogenesis of Late-onset Alzheimer's disease (LOAD) and the Cholesteryl Ester Transfer Protein (CETP) is critical to cholesterol regulation within the cell, making CETP an Alzheimer’s disease candidate gene. Several studies have suggested that CETP I405V (rs5882) is associated with cognitive function and LOAD risk, but findings vary and most studies have...

The application of phase change material (PCM) for energy conservation purposes in the residential buildings was investigated in the present study. Two types of building in terms of materials as the lightweight building (LWB) and heavyweight building (HWB) located in a high cooling load demanding region of Iran were considered for the study. Different types of PCM from organic and inorganic cat...

drug therapy is a complex and important process and because of the importance of drug interactions, especially in in-patients, accompanying problems and obstacles would exist as a result of concomitant use of drugs in these patients. for this purpose 3130 prescription order forms from bou-ali hospital were collected and all potential drug interactions presentwere extracted and evaluated in term...

Carroll has shown three qualitatively different cases of behavior in the load-expansion relation for the inflation of hollow incompressible isotropic elastic spheres. Each of these cases was related to material response in uniaxial compression (or equal biaxial extension). For "type A" materials, load increases monotonically with expansion; for "type B" materials, load increases monotonically a...

Citation: Fernández MV, Budde J, Del-Aguila JL, Ibañez L, Deming Y, Harari O, Norton J, Morris JC, Goate AM, NIA-LOAD family study group, NCRAD and Cruchaga C (2018) Evaluation of Gene-Based Family-Based Methods to Detect Novel Genes Associated With Familial Late Onset Alzheimer Disease. Front. Neurosci. 12:209. doi: 10.3389/fnins.2018.00209 Evaluation of Gene-Based Family-Based Methods to Dete...

We investigated the potential contribution of mitochondrial DNA (mtDNA) variants, haplogroups, and polymorphisms in nuclear genes essential for mitochondrial biogenesis and function (PGC-1α TFAM) to late-onset Alzheimer's disease (LOAD) risk. Epistatic interaction analysis was conducted between the studied variables. Our results demonstrate that mtDNA haplogroups and subhaplogroups with putativ...

In this case-controlled study, we tested susceptible genetic variants for Alzheimer's disease (AD) in CR1, CLU and PICALM from Genome Wide Association studies (GWAS) in southern Chinese population. 812 participants consisting of 462 late-onset Alzheimer's disease (LOAD) patients and 350 non-demented controls were recruited. We found by multivariate logistic regression analysis, that single nucl...