High-resolution airborne Lidar and optical imaging systems with onboard data collection based on the Global Positioning System (GPS) and inertial navigation syste ms (INS) technology may offer the means to gather accurate topographic map information. As a follow-up to earlier investigations, in May 2005 an airborne integrated GPS-aided inertial Lidar and optical imaging system was used to colle...

We describe a reflection imaging system that consists of a plasmonic crystal, a common laboratory microscope, and band-pass filters for use in the quantitative imaging and in situ monitoring of live cells and their substrate interactions. Surface plasmon resonance (SPR) provides a highly sensitive method to monitor changes in physicochemical properties occurring at metal-dielectric interfaces. ...

Phase distortion in wavefront propagation is one of the key problems in optical imaging and laser optics applications. We present a hybrid VLSI and optical system for real-time adaptive phase distortion compensation. The system operates “model-free”, independent of the specifics of the distorting optical medium and the compensation control elements. Our VLSI system implements stochastic paralle...

The synergy between in-room imaging and optical tracking, in co-operation with highly accurate robotic patient handling represents a concept for patient-set-up which has been implemented at CNAO (Centro Nazionale di Adroterapia Oncologica). In-room imaging is based on a double oblique X-ray projection system; optical tracking consists of the detection of the position of spherical markers placed...

Optical imaging techniques are treated with utmost importance due to their noninvasive and relatively inexpensive qualities. They have obvious advantages for continuous monitoring of physiological changes over diagnostic modalities like radiography and computed tomography which utilizes ionic radiation. Tomography is mathematical technique to get cross sectional details of an object from multip...

Optical biopsy facilitates in vivo disease diagnoses by providing a real-time in situ view of tissue in a clinical setting. Fluorescence confocal microendoscopy and optical coherence tomography (OCT) are two methods that have demonstrated significant potential in this context. These techniques provide complementary viewpoints. The high resolution and contrast associated with confocal systems al...

Recently, joint analysis and optimization of both the optical sub-system and the algorithmic capabilities of digital processing have created new digital-optical imaging systems with system-level benefits. We explore a special class of digital-optical imaging systems called spherical coding that combine lens systems having controlled amounts of spherical aberration with digital sharpening filter...

Two-photon fluorescence microscopy provides a powerful tool for deep tissue imaging. However, optical aberrations from illumination beam path limit imaging depth and resolution. Adaptive Optics (AO) is found to be useful to compensate for optical aberrations and improve image resolution and contrast from two-photon excitation. We have developed an AO system relying on a MEMS Deformable Mirror (...

Aberrations in optical microscopy reduce image resolution and contrast, and can limit imaging depth when focusing into biological samples. Static correction of aberrations may be achieved through appropriate lens design, but this approach does not offer the flexibility of simultaneously correcting aberrations for all imaging depths, nor the adaptability to correct for sample-specific aberration...