The objective of the current study was to develop and optimize a sublingual tablet formulation of captopril which is an effective drug in the treatment of hypertension. Captopril containing tablets were prepared by direct compression method using different ingredients such as polyvinyl pyrrolidone, starch 1500, sodium starch glycolate and lactose (independent variables) and magnesium stearate, ...

The circuit optimization process is formulated as a dynamic controllable system. A special control vector is defined to redistribute the compute expense between a network analysis and a parametric optimization. This redistribution permits the minimization a computer time. The problem of a minimal-time circuit optimization can be formulated in this case as a classical problem of the optimal cont...

The objective of the current study was to develop and optimize a sublingual tablet formulation of captopril which is an effective drug in the treatment of hypertension. Captopril containing tablets were prepared by direct compression method using different ingredients such as polyvinyl pyrrolidone, starch 1500, sodium starch glycolate and lactose (independent variables) and magnesium stearate, ...

this paper presents a new optimization algorithm to design an optimal proportional, integral, derivative (pid) controller in hydro-turbine generator governor for damping output frequency oscillations. in this research, we utilize a stochastic and optimal based pid controller to control frequency-response of the hydro turbine. the proposed algorithm is employed to design an optimal pid controlle...

A typical recognition system consists of a sequential combination of two experts, called a detector and classifier respectively. The two stages are usually designed independently, but we show that this may be suboptimal due to interaction between the stages. In this paper we consider the two stages holistically, as components of a multiple classifier system. This allows for an optimal design th...

Order picking accounts for most of the operating expense of a typical distribution center. In discrete order picking a single worker walks to pick all the items necessary to fulfill a single customer order. Discrete order picking is common not only because of its simplicity and reliability, but also because of its ability to pick orders quickly upon receipt, and thus is commonly used by e-comme...

The fundamental theory of the switched reluctance motor is presented with a number of new equations. It is used to show how the practical development of a design calculation should proceed, and this leads to a discussion of physical characteristics required to achieve satisfactory performance and to reduce acoustic noise. The paper makes a few generic observations on the characteristics of succ...

This paper studies a model of interpersonal bundling, in which a monopolist offers a good for sale under a regular price and a group purchase discount if the number of consumers in a group– the bundle size– belongs to some menu of intervals. We find that this is often a profitable selling strategy in response to demand uncertainty, and it can achieve the highest profit among all possible sellin...