Neuromuscular abnormalities developing as a consequence of critical illness can be found in the majority of patients hospitalized in the intensive care unit (ICU) for 1 week or more (1–3). The spectrum of illness ranges from isolated nerve entrapment with focal pain or weakness, to disuse muscle atrophy with mild weakness, to severe myopathy or neuropathy with associated severe, prolonged weakn...

Motor neurone disease (MND) is a devastating and progressive neurological disorder in which degeneration of motor neurones results in weakness and wasting of the dependent muscles. The prevalence of MND is approximately five per 100 000 and approximately 30% of patients have primary bulbar symptoms. Half of the patients die within 36 months of experiencing the first symptom. Presentation with v...

We read with great interest the article by Bach et al 1 in a recent issue of CHEST (May 2010) concerning the application of continuous volume-cycled noninvasive ventilation (NIV) and mechanically assisted coughing (MAC) to successfully extubate patients with neuromuscular disease (NMD) after an episode of acute respiratory failure (ARF). In fact, considering that extubation failure is associate...

BACKGROUND Increasing arginine (Arg) availability reduces atrophy in cultured skeletal muscle cells. Supplementation with its metabolic precursor citrulline (Cit) is more effective at improving skeletal muscle Arg concentrations. OBJECTIVE We tested the hypothesis that Cit supplementation would attenuate skeletal muscle atrophy and loss of function during hindlimb immobilization in mice. ME...

Rationale Few data exist concerning sleep in patients with hemidiaphragm paralysis or weakness. Traditionally such patients are considered to sustain normal ventilation in sleep. Patients&Methods We measured diaphragm strength to identify patients with unilateral paralysis or severe weakness. Patients underwent polysomnography with additional recordings of the transesophageal electromyogram of ...

In restrictive-type anorexia nervosa (AN) patients, physical activity is usually associated with food restriction, but its physiological consequences remain poorly characterized. In female mice, we evaluated the impact of voluntary physical activity with/without chronic food restriction on metabolic and endocrine parameters that might contribute to AN. In this protocol, FRW mice (i.e., food res...

how to cite this article: tonekaboni s.h. juvenile pompe. iran j child neurol autumn 2012; 6:4 (suppl. 1):10.   pls see pdf.

background: diseases that cause acute flaccid paralysis (afp) often progress rapidly, thus may cause life threatening complications, therefore, their diagnosis and cure are important. this study was carried out to investigate the causes of acute generalized weakness in children referred to amirkola children’s hospital, in babol, iran. methods: in this case series, the epidemiological causes of ...

how to cite this article : aminzadeh v, hassanzadeh rad a. a report of guillain–barré syndrome with myalgiaand mild weakness. iran j child neurol. 2014 spring; 8(2):70-72.   we report a rare case that revealed severe myalgia as the chief complaint that is not mentioned in the list of frequent symptoms of guillain barré. guillain-barré syndrome (gbs) is an acute inflammatory demyelinating polyne...