Agents that modulate cellular iron availability have been studied for their antitumor activity. Based on encouraging in vitro studies, the iron chelator deferoxamine (DFO) has been used in clinical studies to treat cancer patients. The observation that DFO induced macular edema in several cancer patients led to the present investigation of vascular endothelial growth factor (VEGF) as a possible...

Several efforts have been made to detoxify the effect of metals once they are administered in the human body. Chelation is considered the best method used so far. Medicinal treatment of acute and chronic metal toxicity is provided by chelating agents. Chelation is one of the chemical functions that take place in the bodies of almost all living organisms. It is a process by which plants and anim...

Agents that modulate cellular iron availability have been studied for their antitumor activity. Based on encouraging in vitro studies, the iron chelator deferoxamine (DFO) has been used in clinical studies to treat cancer patients. The observation that DFO induced macular edema in several cancer patients led to the present investigation of vascular endothelial growth factor (VEGF) as a possible...

Affibody molecules constitute a class of small (7 kDa) scaffold proteins that can be engineered to have excellent tumor targeting properties. High reabsorption in kidneys complicates development of affibody molecules for radionuclide therapy. In this study, we evaluated the influence of the composition of cysteine-containing C-terminal peptide-based chelators on the biodistribution and renal re...

In a recent article, we presented the hypothesis that decompartmentalized metal ions are a major contributor to the development of diabetic complications and supported the use of chelation therapy for the treatment of diabetic complications [Nagai R, Murray DB, Metz TO, Baynes JW. Chelation: a fundamental mechanism of action of AGE inhibitors, AGE breakers, and other inhibitors of diabetes comp...

Toxic metals such as arsenic, cadmium, lead, and mercury are ubiquitous, have no beneficial role in human homeostasis, and contribute to noncommunicable chronic diseases. While novel drug targets for chronic disease are eagerly sought, potentially helpful agents that aid in detoxification of toxic elements, chelators, have largely been restricted to overt acute poisoning. Chelation, that is mul...

The purpose of this review is to briefly summarize the central role iron (Fe) in terms cellular alterations oxidative/protective balance with special emphasis on its possible involvement ferroptosis-dependent disruption aquatic organisms. In ferroptotic cells or tissues, intracellular Fe level increases; meanwhile treatment chelators limits ferroptosis. Eukaryotic algae can assimilate from envi...

The world’s arable land has been contaminated by heavy metals to a large extent, which led the decreasing availability of farmland. Thus, remediation metal pollution deserves due attention, and phytoremediation is preferred. Hemp proposed as an ideal alternative crop for remediating heavy-metal-contaminated soil, owing its well-developed roots, biomass, tolerance metals. Chelators can activate ...

absorbed in the intestine mainly through the paracellular pathway. Their oral bioavailability is usually low since this pathway is severely restricted by the presence of the tight junctions. One of the possible strategies for solving this problem would be a controlled and reversible opening of the tight junctions, which could be achieved by compounds called paracellular permeability enhancers (...

Acute iron intoxication is a frequent, sometimes life-threatening, form of poisoning. Present therapy, in severe cases, includes oral and intravenous administration of the potent iron chelator, deferoxamine. Unfortunately, high dose intravenous deferoxamine causes acute hypotension additive with that engendered by the iron poisoning itself. To obviate this problem, we have covalently attached d...