BACKGROUND The development of oral squamous cell carcinoma (OSCC) is a multistep process that involves in both genetic alterations and epigenetic modifications. Previous studies suggest SOX4 might function as an oncogene or a tumor suppressor in different types of cancers. However, whether SOX4 involves in promoting the progression of oral precancer to cancer is unknown. METHODS Liquid chroma...

Oral lichen planus (OLP) is a chronic mucosal condition commonly encountered in dental practice. Lichen planus is believed to represent an abnormal immune response in which epithelial cells are recognized as foreign, secondary to changes in the antigenicity of the cell surface. It has various oral manifestations. The aim of the study was to evaluate the morphological characteristics of microcir...

Background and Objectives: Oral lichen planus (OLP) is a common T-cell-mediated inflammatory oral mucosal disease. One of the complaints among OLP patients xerostomia. However, relationship between dryness decreased salivary-flow rate in these not yet conclusive. So, we investigated using various measurements. Material Methods: Thirty 30 controls were included. The oral-dryness symptoms collect...

Interleukin- (IL-) 23/IL-17 axis is a newly discovered proinflammatory signaling pathway and has been implicated in the pathogenesis of many chronic inflammatory and immune disorders. Here we investigated whether the IL-23/IL-17 axis was present and functional in the lesions of oral lichen planus (OLP), a chronic inflammatory disease affecting the oral mucosa. Using immunohistochemistry and qua...

objectives : lichen planus (lp) is a chronic inflammatory mucocutaneous disease. its treatment is often symptomatic and includes topical and systemic corticosteroids. although corticosteroid therapy is usually successful, it has side effects and thus, an alternative treatment is favorable. the aim of this study was to compare the efficacy of topical curcumin and triamcinolone for treatment of o...

Background: Oral lichen planus (OLP) is a relatively common chronic inflammatory muco-cutaneous disease classified among the potentially malignant lesions of oral mucosa. In this study we evaluated tissue expression of p53، ki-67 in OLP compared to normal oral mucosa. Methods: Specimens (formalin-fixed and paraffinembedded) of 44 lesions of OLP and 30 controls referred to immunohistochemistry (...

Oral lichen planus which is one of the most common oral mucosal diseases in adults, it has been rarely described in children. There are very reports in the literature regarding oral lichen planus in children, here we report a case of intraoral lesions of lichen planus. Lichen planus should be considered in the differential diagnosis of hyperkeratotic or erosive lesions of the oral mucosa in chi...

BACKGROUND Lichen planus (LP) is a mucocutaneous inflammatory dermatosis that frequently involves the oral and genital mucosae. Patients with LP affecting these sites are often seen by oral medicine specialists or gynaecologists who work in isolation and depend heavily on histopathologists to help them in confirming the diagnosis. There are few studies in the literature combining the experience...

AIMS At present oral lichen planus (OLP) is classified among precancerous conditions but very few data are available in literature regarding prognosis of OLP-related cancers. The aim of this paper is to evaluate clinical long-term behaviour of OLP-related oral squamous cell carcinomas (OSCCs). METHODS Clinical history and data from follow-up regarding 21 patients undergoing malignant transfor...

Editor Coeliac disease (CD) is a chronic immune-mediated disease, triggered by gluten ingestion in genetically susceptible subjects resulting in small intestinal mucosal injury with subsequent nutrient malabsorption. CD is a disease with a heterogeneous and often unsuspected range of clinical presentations; its ‘typical’ presentation, characterized by a gastrointestinal manifestations, is less ...