Objective : The anti-tumor effect of the beta-adrenergic receptor antagonist propranolol in breast cancer is well known; however, its activity glioblastoma not well-evaluated. Notch-Hes pathway known to regulate cell differentiation, proliferation, and apoptosis. We investigated human lines, role Notch Hes signaling this process.Methods performed immunohistochemical staining on 31 surgically re...

Previous studies have suggested that dopamine may have an important role as an inhibitor of aldosterone secretion in humans. Recent studies have also suggested that the adrenergic nervous system may have an important role in controlling aldosterone secretion. The present study investigated the effects of dopamine on aldosterone secretion in response to angiotensin II, with and without pretreatm...

The therapeutic arsenal for hemangiomas in early childhood can now be considered to include oral β-blockers, mainly propranolol. These drugs are thought to act as vasoconstrictors, regulating angiogenic pathways and inducing apoptosis of vascular endothelial cells. Although infantile hemangioma is not among the approved indications for β-blockers, many specialized clinics will prescribe propran...

Previous studies have suggested that dopamine may have an important role as an inhibitor of aldosterone secretion in humans. Recent studies have also suggested that the adrenergic nervous system may have an important role in controlling aldosterone secretion. The present study investigated the effects of dopamine on aldosterone secretion in response to angiotensin II, with and without pretreatm...

When D,L-propranolol, 100 mg/kg/day, was added to the drinking water of spontaneously hypertensive rats (SHR), systolic pressures measured with the tail-cuff method fell significantly within 1 month and were almost the same as those in normotensive controls (KNR) by the end of 3 months. This antihypertensive effect was later confirmed by direct recording of phasic aortic pressures from indwelli...

BACKGROUND Migraine is a common neurological disease affecting 12% of Americans and millions worldwide. Medication adherence has been studied extensively in many chronic conditions, with poor adherence adversely affecting treatment outcomes. However, little is known about adherence to oral prophylaxis for migraine. OBJECTIVE To examine the literature on assessing oral prophylaxis medication a...

Purpose: The objective of the study was to evaluate the naturally available Moringa gum as drug carrier and mucoadhesive component in buccal delivery and to compare the bioavailability of Propranolol Hydrochloride buccal tablet with the oral tablet in healthy human volunteers. Material and Methods: The buccal tablets containing various concentration (Formulation1: 10, F2: 20, F3: 30 and F4: 40 ...

<p>Hemangiomas of the airway are benign vascular lesions that can involve any site from nares to tracheobronchial tree. It is most common head and neck tumors in infants. Most these seen subglottic area The presence supraglottic hemangioma rarely described. This may be due less likely chance symptoms tendency infantile hemangiomas involute without therapy over time. Also, occurrence as a ...

: Trichodynia was elucidated as a distressing, painful sensation of the scalp hair and/or skin that becomes more vigorous when hairs are touched without an underlying cutaneous disease and is frequently associated with shedding. It often in women than men, directly correlating loss. The etiology trichodynia not well-known, but it may be multifactorial. Several possible hypotheses can explain et...