Kaposi’s sarcoma has emerged from being a rarity to being the most important neoplasm in many sub-Saharan countries. Most investigators involved in Kaposi’s sarcoma research now agree that the gammaherpesvirus human herpesvirus 8 (HHV8), also called Kaposi’s sarcoma-associated herpesvirus (KSHV), is central in the pathogenesis of this disease (1,2). Molecular and seroepidemiologic studies (3,4)...

Objective: The molecular targeted drug pazopanib is a selective oral tyrosine kinase inhibitor that exerts its effects on vascular endothelial growth factor receptors (VEGF-R) and inhibits angiogenesis. This study aimed to examine the therapeutic efficacy, incidence of adverse events (AEs), and dosage of pazopanib in Japanese patients with metastatic or unresectable advanced soft tissue sarcoma...

UNLABELLED HIV/AIDS infection in Bulgaria has spread over about 1200 registered patients and it is supposed that the number of the undetected cases is four times higher. Kaposi's sarcoma is rarely observed in our country and no cutaneous-mucosal dissemination is reported for the time being. AIM The aim of the study is to present a case of disseminated Kaposi's sarcoma in a HIV/ AIDS patient w...

HIV/AIDS infection in Bulgaria has spread over about 1200 registered patients and it is supposed that the number of the undetected cases is four times higher. Kaposi’s sarcoma is rarely observed in our country and no cutaneous-mucosal dissemination is reported for the time being. Aim: The aim of the study is to present a case of disseminated Kaposi’s sarcoma in a HIV/ AIDS patient who underwent...

UNLABELLED Background. Kaposi sarcoma (KS) is one of the most common neoplasms diagnosed in HIV-seropositive subjects. Oral involvement is frequent and is associated with a poor prognosis. The aim of this study was to characterize the features of oral HIV-KS in patients from Ga-Rankuwa, South Africa. Methods. All cases with confirmed oral HIV-KS treated at the oral medicine clinic in Ga-Rankuwa...

This report outlines the workup and management of a 55-year-old woman with a synovial sarcoma of the lateral border of the tongue that was initially diagnosed as a glomus tumor. A review was performed of the literature on synovial sarcomas of the oral cavity and current National Comprehensive Cancer Network guidelines. Synovial sarcomas of the tongue are rare neoplasms, with variable morphologi...

The oral microbial community (microbiota) plays a critical role in human health and disease. Alterations in the oral microbiota may be associated with disorders such as gingivitis, periodontitis, childhood caries, alveolar osteitis, oral candidiasis and endodontic infections. In the immunosuppressed population, the spectrum of potential oral disease is even broader, encompassing candidiasis, ne...

primary kaposi sarcoma of penis is very rare. we will introduce a 47 years old male patient referred to our clinic from dermatology service, in this report. the patient suffered from itchy penile papules around coronal region. the lab tests had revealed a negative serology of hiv but tissue pcr was positive for human herpesvirus-8 (hhv8).  histological findings were compatible with kaposi sarco...

Abstract Follicular dendritic cell (FDC) sarcoma, a rare tumor of FDCs, poses diagnostic challenge due to its myriad morphologic and architectural patterns. We present unique case extra-nodal FDC sarcoma occurring in 28-year-old gentleman who presented with multiple pelvic, peritoneal retroperitoneal soft tissue, axial skeletal lesions. The was composed islands trabeculae epithelioid cells inte...

testicular chloroma is an unusual form of extramedullary acute myeloid leukemia. we present a rare case that after chemotherapy relapsed with the appearance of metachronous testicular chloroma and we suggest prophylactic radiotherapy.