Smokeless tobacco consumption, which is widespread throughout the world, leads to oral submucous fibrosis (OSMF), which is a long-lasting and devastating condition of the oral cavity with the potential for malignancy. In this review, we mainly focus on the consumption of smokeless tobacco, such as paan and gutkha, and the role of these substances in the induction of OSMF and ultimately oral can...

Pseudomonas aeruginosa is the major bronchopulmonary pathogen affecting adolescents and adults with cystic fibrosis.' It is not susceptible to any oral antimicrobial agents generally available and is conventionally treated with intravenous chemotherapy. In patients requiring frequent or prolonged treatment, however, thrombophlebitis of peripheral veins may necessitate central venous access. We ...

OBJECTIVES Oral cancer (OC) may be preceded by clinically evident oral potentially malignant disorders (OPMDs). Oral carcinogenesis is a multistep process that begins as epithelial hyperplasia and progresses to oral epithelial dysplasia and finally to fully malignant phenotypes. The aim of our study was to estimate the prevalence of OPMDs in a large population of dental patients. METHODS Pati...

One precancerous condition with a high potential to turn into malignancy and pose risk is OSMF (oral submucous fibrosis) which mainly affects the young subjects globally as well in India. The etiology of attributed gutkha chewing habit. Another predominant etiologic factor governing etiopathogenesis malignant premalignant lesions Candida species. Our aim present clinical study was conducted ass...

Executive Summary The lumacaftor and ivacaftor fixed dose combination oral tablet (OrkambiTM, Vertex Pharmaceuticals, Inc.) is the second Food and Drug Administration (FDA) approved member of a new pharmacologic class of drugs termed cystic fibrosis transmembrane conductance regulator (CFTR) modulators.[1] CFTR modulators target the underlying defect (reduced CFTR function) that causes disease ...

Oral submucous fibrosis (OSF) is characterized by excessive fibrosis of submucosa. The degree of vascularity in OSF has always been a matter of debate. Angiogenesis is the key mechanism involved in regeneration and repair. It also plays an important role in various pathologic conditions. Angiogenesis may contribute to the progression of fibrosis in fibrotic disorders. Inhibition of pathological...