نتایج جستجو برای: orexin

تعداد نتایج: 2583  

1999
TETSURO SHIRASAKA MASAMITSU NAKAZATO SHIGERU MATSUKURA MAYUMI TAKASAKI HIROSHI KANNAN Masamitsu Nakazato Shigeru Matsukura Mayumi Takasaki

Shirasaka, Tetsuro, Masamitsu Nakazato, Shigeru Matsukura, Mayumi Takasaki, and Hiroshi Kannan. Sympathetic and cardiovascular actions of orexins in conscious rats. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1780–R1785, 1999.—The novel hypothalamic peptides orexin-A and orexin-B are known to induce feeding behavior when administered intracerebroventricularly, but little is...

Journal: :Nuclear medicine and biology 2013
Changning Wang Colin M Wilson Christian K Moseley Stephen M Carlin Shirley Hsu Grae Arabasz Frederick A Schroeder Christin Y Sander Jacob M Hooker

A wide range of central nervous system (CNS) disorders, particularly those related to sleep, are associated with the abnormal function of orexin (OX) receptors. Several orexin receptor antagonists have been reported in recent years, but currently there are no imaging tools to probe the density and function of orexin receptors in vivo. To date there are no published data on the pharmacokinetics ...

Journal: :Physiological research 2004
M Monda An Viggiano Al Viggiano F Fuccio V De Luca

This experiment tested the effect of clozapine on the sympathetic and thermogenic effects induced by orexin A. The firing rates of the sympathetic nerves to interscapular brown adipose tissue (IBAT), along with IBAT and colonic temperatures were monitored in urethane-anesthetized male Sprague-Dawley rats before and for 5 h after an injection of orexin A (1.5 nmol) into the lateral cerebral vent...

Journal: :Behavioural brain research 2011
Thomas Fenzl Christoph P N Romanowski Cornelia Flachskamm Jan M Deussing Mayumi Kimura

It is widely accepted that orexin (hypocretin) bears wake-promoting effects. While under normal conditions the circadian rhythm of orexin release has a clear circadian distribution, the amplitude of orexin fluctuation is dampened in depression. Interestingly, clinical symptoms of depression include several sleep disturbances. In this disease, corticotropin-releasing hormone (CRH) seems to be an...

2015
Xiaocen Chang Yuyan Zhao Lei Guo

Orexin-A is a neuropeptide that orchestrates diverse central and peripheral processes. It is now clear that orexin system plays a central role in the regulation of endocrine, paracrine, and neurocrine. It is involved in the regulation of growth hormone, adrenocorticotropic hormone, thyroid, mineralocorticoid, and cortisol secretion. These hormones may also serve as a kind of signal linking ener...

2017
África Flores Cyril Herry Rafael Maldonado Fernando Berrendero

Background Orexins are hypothalamic neuropeptides recently involved in the regulation of emotional memory. The basolateral amygdala, an area orchestrating fear memory processes, appears to be modulated by orexin transmission during fear extinction. However, the neuronal types within the basolateral amygdala involved in this modulation remain to be elucidated. Methods We used retrograde tracin...

Journal: :The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2002
María J Sánchez de Miguel María A Burrell

Orexins are novel neuropeptides that were originally localized in neurons of the hypothalamus and neuronal fibers of the brain. Recently orexin A and its receptor have also been reported in neurons and endocrine cells of the gastrointestinal tract. Because no studies have been done at the embryonic period, we studied the appearance and distribution of orexin A during the development of mouse ga...

2015
Tomoyuki Kuwaki

In the past, studies on stress responses and sleep/wake regulation were performed separately. The discovery of orexin (hypocretin) in 1998, however, dramatically changed the course of research and new findings regarding its role in these complex processes provided a better insight into their interactions and intricacies. Orexin-containing neuronal activity has been found to be minimal during sl...

2016
Yasuhiro Ogawa Yoko Irukayama-Tomobe Nobuyuki Murakoshi Maiko Kiyama Yui Ishikawa Naoto Hosokawa Hiromu Tominaga Shuntaro Uchida Saki Kimura Mika Kanuka Miho Morita Michito Hamada Satoru Takahashi Yu Hayashi Masashi Yanagisawa

Sepsis is a systemic inflammatory response to infection, accounting for the most common cause of death in intensive care units. Here, we report that peripheral administration of the hypothalamic neuropeptide orexin improves the survival of mice with lipopolysaccharide (LPS) induced endotoxin shock, a well-studied septic shock model. The effect is accompanied by a suppression of excessive cytoki...

2017
Mariusz Sieminski Kamil Chwojnicki Tomi Sarkanen Markku Partinen

STUDY OBJECTIVE Narcolepsy type 1 (NT1) is caused by a deficiency or absence of the neurotransmitter orexin. NT1 is also associated with a reduced nocturnal "dipping" of blood pressure (BP). The study objective was to analyze whether nocturnal BP values differed in patients depleted of orexin, versus those in whom production was preserved. METHODS We performed a retrospective analysis of the ...

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