BACKGROUND & OBJECTIVES The main cause of morbidity due to organophosphate poisoning is intermediate syndrome (Type II paralysis) that can occur 48-72 h after poisoning. Mechanisms that underlie the intermediate syndrome are not known. This study investigates the role of oxidative damage to muscles as a possible mechanism underlying the development of the intermediate syndrome. METHODS Ninete...

This project was primarily funded by a contract with the Department of Pesticide Regulation (DPR) of the California Environmental Protection Agency. The contract was supported by an allotment dedicated to the pesticide monitoring priorities of the California Regional Water Quality Control Boards. The statements and conclusions in this report are those of the contractor and not necessarily those...

The enhanced degradation of organophosphorous-based chemical warfare agents (CWAs) on metal-oxide surfaces holds immense promise for neutralization efforts; however, the underlying mechanisms in this process remain poorly understood. We utilize large-scale quantum calculations first time to probe high-temperature diisopropyl methylphosphonate (DIMP), a nerve agent simulant. Our Born-Oppenheimer...