Orofacial pain is a prevalent symptom in modern society. Some musculoskeletal orofacial pain is caused by temporomandibular disorders (TMDs). This condition has a multi-factorial etiology, including emotional factors and alteration of the masticator muscle and temporomandibular joints (TMJs). TMJ inflammation is considered to be a cause of pain in patients with TMD. Extracellular proteolytic en...

Folic acid and the methylenetetrahydrofolate reductase (MTHFR) gene have both been implicated in the etiology of orofacial clefts. The authors selected 261 case-parent triads (173 cases with cleft lip with or without cleft palate (CL/P) and 88 cases with cleft palate only (CPO)) from a Norwegian population-based study of orofacial clefts (May 1996-1998). A case-parent triad design was used to e...

Uke most other specialty areas, orthodontics has a rich professional literature containing disagreement and debate on a number of topics. One area of controversy since the inception of orthodontics in the late 1800s is the relationship between tongue functions and the development of malocclusions. Many orthodontists continue to believe strongly that tongue functions cause certain types of maloc...

Nevet, Alon, Genela Morris, Guy Saban, Nina Fainstein, and Hagai Bergman. Discharge rate of substantia nigra pars reticulata neurons is reduced in non-parkinsonian monkeys with apomorphineinduced orofacial dyskinesia. J Neurophysiol 92: 1973–1981, 2004. First published April 28, 2004; 10.1152/jn.01036.2003. Involuntary movements (dyskinesia) are a common symptom of dopamine-replacement therapy ...

Stem cells from human exfoliated deciduous teeth have been identified as a new post-natal stem cell population with multipotential differentiation capabilities, including regeneration of mineralized tissues in vivo. To examine the efficacy of utilizing these stem cells in regenerating orofacial bone defects, we isolated stem cells from miniature pig deciduous teeth and engrafted the critical-si...

Dr Dermot Canavan BDentSc, MGDS (Edin), MS U Calif 69 Eglinton Road, Donnybrook, Dublin 4 Tel: 01 2694022 Fax: 01 2694004 Introduction Orofacial pain is an important issue for both patients and clinicians alike. Pain within the oral cavity is most frequently dental in origin (odontogenic) and extra-orally the most common source of pain is musculoskeletal (TMD). Once these conditions have been e...

Disorders involving the orofacial area represent a major medical and social problem. They are a consequence of central nociceptive processes associated with stimulation of the trigeminal nerve nucleus. A rat model of trigeminal pain, utilizing tongue jerks evoked by electrical tooth pulp stimulation during perfusion of the cerebral ventricles with various neuropeptide solutions, can be used in ...

This study aimed to examine whether trigeminal nerve injury induces chronic nociceptive behaviour and central sensitization (CS) in functionally identified medullary dorsal horn (MDH) nociceptive neurons in mice, and whether CS in acute and chronic orofacial pain models and nociceptive behaviour in the chronic model are affected by systemic administration of pregabalin. Infraorbital nerve injur...

OBJECTIVE To define the intrinsic (hypoplasia) and extrinsic (deformational) contributions to congenital nasal deformities and the potential of a carrier state for orofacial clefting. METHODS Retrospective case series. RESULTS The factors affecting 4 congenital nasal deformities are postulated after contrasting the patient's characteristics. CONCLUSIONS The spectrum of congenital nasal de...

OBJECTIVE Cultural or ethnic factors may play an important role in subjects' pain reports. The aim of the study was to compare the prevalence of orofacial pain symptoms between Finnish and Thai populations. MATERIALS AND METHODS The Finnish study population comprised the Northern Finland Birth Cohort 1966, of which 5696 subjects participated in the present study. The Thai sample consisted of ...