The complete nucleotide sequence of tobacco rattle virus (TRV) strain SYM RNA-1 was determined from a series of overlapping cDNA clones. cDNA prepared by primer extension was used to determine the exact 5' terminus. The RNA sequence was 6791 nucleotides in length and contained four open reading frames (ORFs). The ORF nearest the 5' terminus coded for a polypeptide of predicted mol. wt. 134,000 ...

Small cell lung cancer (SCLC) is a highly aggressive tumor with early primary resistance and modest clinical response to immune checkpoint blockade (ICB). Mutations or transcriptional repression of the major histocompatibility complex class I (MHC-I) represent key mechanism driving T cell-based therapies. Lysine-specific demethylase 1 (LSD1) regulates gene expression via demethylating lysines 4...

ion of categorical information. Journal of Ex-perimental Psychology: Learning, Memory, and Cog-nition. Medin, D. L., & Schaffer, M. M. (1978). Context theory of classification learning. Psychological Review, 85, 207-238. Mclcalfe, J., & Murdock, B. B., Jr. (1981). An encodingand retrieval model of single-trial free recall. Journalof Verbal Learning and Verbal Behavior, 20, 1...

Background: Small cell lung cancer (SCLC) is a highly aggressive and lethal tumor. Rapid response to chemotherapy radiotherapy observed in the majority of patients, but most them relapse within 6 12 months. Despite recent addition immunotherapy front-line chemotherapy, improvements progression-free overall survival are modest, with deaths occurring year diagnosis. SCLC heterogeneous can be divi...

T h e Im pulse A d ap tab le M e m o ry S ystem exp oses D R A M access patterns not seen in conven tion al m em ory system s. F or instance, it can generate 32 D R A M a ccesses ea ch o f w h ic h requests a fou r-byte w ord in 32 c yc le s . C on ven tion al D R A M b acken d s are o p tim ized for a ccesses that request fu ll cach e lines. T h e y m ay not b e able to handle sm aller a ccess...

Dear Editor, We read with interest the article from Moghtaderi et al. [1] showing that exposure to horses among individuals who ride enhances the risk of developing allergic sensitization to horse allergens in comparison to healthy controls. The topic is of high importance considering the popularity of a horse as a domestic animal for several reasons (work, leisure, pet therapy, etc.), and the ...

Static symbolic factorization coupled with supernode partitioning and asynchronous computation scheduling can achieve high giga op rates for parallel sparse LU factorization with partial pivoting This paper studies properties of elimination forests and uses them to optimize supernode partitioning amalgamation and execution scheduling It also proposes supernodal matrix multiplication to speed up...

Con cep tual and meth od olog i cal ap proaches from cog ni tive sci ence have in creas ingly been ap plied to re search ex am in ing the re la tion be tween trauma, dis so ci a tion and ba sic cog ni tive func tion ing. The cur rent study rep li cates and ex tends re cent re search that ex am ined per for mance in a di rected for get ting task us ing PTSD and trauma his tory as the group ing v...

The paper investigates the stability properties of markets with backward bending supply curves. Parameters are chosen so that the two classic models of price dynamics, the Walrasian model and the Marshallian model, give opposite predictions. The results are: (1) market instability can be observed; (2) in the backward bending case stability is captured by the Walrasian model and the Marshallian ...