Osteoarthritis (OA) is a chronic progressive degenerative disease of synovial joints that leads to articular cartilage erosions, osteophyte formation, subchondral bone sclerosis and porosity, synovial hyperplasia and capsular fibrosis. The clinical outcome is pain and a reduction of function. OA has a diverse etiology, the mechanisms of the disease are highly complex and it's trajectory is vari...

Osteoarthritis is a degenerative joint disease and a world-wide healthcare burden. Characterized by cartilage degradation, subchondral bone thickening and osteophyte formation, osteoarthritis inflicts much pain and suffering, for which there are currently no disease-modifying treatments available. Mouse models of osteoarthritis are proving critical in advancing our understanding of the underpin...

Diffuse Idiopathic Skeletal Hyperostosis (DISH) is a condition characterized by calcification and ossification of soft tissues, mainly ligaments and enthesis. Dysphagia is the commonest complaint, stridor secondary to osteophyte compression has rarely been documented. The osteophytes may cause symptoms by mechanical compression or by inducting inflammatory reaction. When an upper segment of the...