Adnexal masses are common in gynecology practice and the decision to treat the patient by observation, laparoscopy, or laparotomy will often depend upon basic evaluation in various age groups of women. In the United States, a woman has a 5-10% lifetime risk of undergoing surgery for an adnexal mass and, of these, benign neoplasms constitute a significant number, but 4% of new ovarian cancers ex...

Uterine tumors resembling ovarian sex cord tumors (UTROSCT) are rare, usually benign, polypoid or nodular neoplasms which generally arise in the fourth to sixth decade of life. We report a case of a 74-year-old woman who presented with vaginal bleeding and remarkable uterine enlargement. Abdominal hysterectomy with bilateral salpingo-oophorectomy was performed and a diagnosis of UTROSCT was mad...

Surgery is the primary therapeutic strategy for most solid tumours; however, modern oncology has established that neoplasms are frequently systemic diseases. Being however a local treatment, the mechanisms through which surgery plays its systemic role remain unknown. We have investigated the influence of cytoreduction on the immune system of primary and recurrent ovarian cancer. All ovarian can...

We report on an exceedingly rare case of cutaneous and uterine leiomyomatosis in a 58-year-old Caucasian woman associated with ovarian cystadenoma and complete deletion of the fumarate hydratase gene. All patients and their family members with verified mutation have to be regularly screened for associated neoplasms, in particular papillary renal cell carcinoma (HLRCC, hereditary leiomyomatosis ...

Primary ovarian choriocarcinoma arising from a germ cell is an extremely rare occurrence, especially in postmenopausal women, and the prognosis is poor. Non-gestational choriocarcinoma of the ovary (NGCO) accounts for 0.6% or less of all ovarian neoplasms. It is important to distinguish gestational choriocarcinomas of the ovary (GCO) from other carcinomas because of the poor prognosis of NGCO. ...

We present a female child with Peutz-Jeghers syndrome (PJS) with a recurrent ovarian Sertoli-Leydig cell tumor (SLCT). SLCTs are relatively rare sex cord neoplasms that can occur in PJS. The patient was an African-American female who first presented at the age of 3 years with precocious puberty, and then at the age of 17 years with abdominal pain and irregular menses. In each case, she had rese...

The article by Trimble and Trimble nicely summarizes the state of knowledge on ovarian tumors of low malignant potential (LMP) and underscores the fact that gaps in that knowledge have led to confusion and controversy regarding several issues related to these interesting neoplasms. Many of these controversies can be characterized as debates between the "lumpers" and the "splitters.' The Johns H...

Ovarian steroid cell tumours (not otherwise specified) are rare neoplasms of the ovary and are classified under lipid cell tumours. Their diagnosis can be considered as one of exclusion. Histopathologically, the tumour should carefully be evaluated for microscopic features of malignancy, but it is essential for the clinician and the pathologist to remember that in these tumours, pathologically ...

OBJECTIVE Brenner tumors are rare neoplasms of the ovary. The aim of this study was to investigate the clinical features of Brenner tumors. MATERIALS AND METHODS The clinical features of 22 patients who were treated in Ankara University Faculty of Medicine Obstetrics and Gynecology Department between 2005 and 2015 were evaluated retrospectively from hospital medical records. RESULTS The pat...

Historically misunderstood to be rare and relatively benign, neuroendocrine tumors (NETs) are increasingly common and are now regarded as malignant neoplasms that can cause debilitating symptoms and potentially life threatening issues for patients. Neuroendocrine tumors are a heterogeneous group of separate clinico-pathological entities that share a common characteristic i.e. expression of endo...