OBJECTIVE to compare the overload of the main and secondary family carers of patients with Alzheimer's Disease, and identify which dimension generates most impact. METHOD a comparative study conducted in the city of Maringá, State of Paraná, with 20 primary carers of elderly patients with Alzheimer's Disease and 20 secondary caregivers. The data was collected in May and June 2012, using the S...

Antagonists of the mineralocorticoid receptor improve morbidity and mortality in patients with severe heart failure. However, the cell types involved in these beneficial effects are only partially known. The aim of this work was to evaluate whether genetic deletion of mineralocorticoid receptors in mouse cardiomyocytes or fibroblasts in vivo is cardioprotective after chronic left ventricular pr...

Volume 41, January 2001 TRANSFUSION 123 Hemochromatosis occurs in approximately 1 in 200 white persons of Western European descent, and it increases the propensity to absorb excess iron. Iron overload associated with hemochromatosis can cause hepatic cirrhosis, primary liver cancer, arthropathy, diabetes mellitus, other endocrinopathic disorders, and a reduction in lifespan.1,2 These complicati...

Congestive heart failure (CHF) is the inability of the heart to deliver a sufficient oxygen supply to meet the metabolic demands of the tissues at normal filling pressures, both at rest and during exercise. CHF may arise from reduced inotropy, volume overload, pressure overload, or reduced diastolic dilatation.1 Long-standing hypertension causes CHF by increased pressure overload. With time’s p...

Cardiac side population cells (CSPs) are promising cell resource for the regeneration in diseased heart as intrinsic cardiac stem cells. However, the relative low ratio of CSPs in the heart limited the ability of CSPs to repair heart and improve cardiac function effectively under pathophysiological condition. Which factors limiting the proliferation of CSPs in diseased heart are unclear. Here, ...

We have previously shown that genetic ablation of melusin, a muscle specific beta 1 integrin interacting protein, accelerates left ventricle (LV) dilation and heart failure in response to pressure overload. Here we show that melusin expression was increased during compensated cardiac hypertrophy in mice subjected to 1 week pressure overload, but returned to basal levels in LV that have undergon...

SIP (Session Initiation Protocol) has been widely adopted as a signaling protocol to establish, modify and terminate media sessions between end-users in the Internet. SIP introduces a retransmission mechanism to ensure the reliability of its real-time message delivery. However, retransmission can make server overload worse, leading to server crashes in SIP-based carrier networks (e.g. Skype). I...

Research has shown that excessive email use leads to feelings of being overwhelmed and stressed. Existing coping solutions, which mitigate email overload, address the number of emails and, in consequence, the time spent on emails. These approaches are congruent with existing research on antecedents of email overload. Further coping solutions include addressing email threads. However, we lack a ...

Different from the direct contact in epidemics spread, overload failures propagate through hidden functional dependencies. Many studies focused on the critical conditions and catastrophic consequences of cascading failures. However, to understand the network vulnerability and mitigate the cascading overload failures, the knowledge of how the failures propagate in time and space is essential but...

Iron overload remains a concern in MDS patients especially those requiring recurrent blood transfusions. The consequence of iron overload may be more relevant in patients with low and intermediate-1 risk MDS who may survive long enough to experience such manifestations. It is a matter of debate whether this overload has time to yield organ damage, but it is quite evident that cellular damage an...