The restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ovine TRIM5α effectively restricted the lentivirus visna/maedi virus DNA synthesis. Proteasome inhibition in cells transduced with ovine TRIM5α restored restricted viral DNA synt...

The current investigation was undertaken to study whether mammalian prolactin can induce mitotic activity in the anterior pituitary gland in chicks. It was found that intramuscular injections of ovine prolactin (1.5 i.u. and 10 i.u. each daily per bird for 10 days) significantly increased mitotic frequency in the adenohypophysis of juvenile cockerels. It is suggested that ovine prolactin has a ...

The somatogenic and galactopoietic effects of recombinant ovine placental lactogen (oPL) were compared with the effects of recombinant ovine growth hormone (oGH) in post-weaned growing lambs and in lactating ewes. In two experiments that each lasted 35 days, 2-month-old lambs were given daily subcutaneous injections (0.1 mg/kg live weight) of oPL or oGH, and their daily growth rates were compar...

INTRODUCTION: Few options exist to repair damaged knee menisci, oftentimes leading to a partial or full meniscectomy. However, removal of meniscal tissue can result in joint degeneration, therefore scaffolds designed to elicit rapid infiltration of cells and tissue growth in the defect site are under development. The objective of this study was to assess the long-term in vivo performance of a b...