Cerdulatinib (DMVT-502) is an investigational kinase inhibitor with demonstrated activity against Jak and SYK (Coffey et al., 2014Coffey G. Betz A. DeGuzman F. Pak Y. Inagaki M. Baker D.C. al.The novel PRT062070 (cerdulatinib) demonstrates efficacy in models of autoimmunity B-cell cancer.J Pharmacol Exp Ther. 2014; 351: 538-548Crossref PubMed Scopus (51) Google Scholar). There are currently no ...

Central MessageA compendium of Feature Expert Opinion in the Journals American Association for Thoracic Surgery highlights hot topics congenital heart surgery years 2020-2021. A The rapid progress and ever-expanding volume literature cardiothoracic children adults with disease necessitates providing our busy readership condensed cohesive information extracted from all 6 journals Surgery. Our Ed...

The present study tested the hypothesis (Byrne, 1996) that young children who do not yet understand that the elements of alphabetic writing represent phonemes link writing to language at the level of morphemes. We asked US preschoolers to write words that varied in the number of morphemes and the number of syllables that they contained. We identified a group of 50 children who used letters that...

Male Wistar rats were trained to discriminate either the opioid receptor like (ORL)-1 receptor agonist Ro 64-6198 (1S,3aS-8– 2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one) or morphine from saline using a twochoice, food reinforced, operant procedure. Acquisition of Ro 64-6198 discrimination was relatively slow (mean trials to criterion 113 6), and a final 4 ...

s | 23 reduction of inflammatory markers. Next PG decreases microglia activation after FCI. Our finding suggests that neuroactive steroids have a relevant role in the prevention of ischemic outcome in immature brain. This study was supported by grants GACR P304/12/G069, P304/14/20613S, P303/12/1464, GAUK project No.165115, TACR-TE01020028 and institutional support RVO: 67985823 and CZ.2.16/3.1....

Orphanin FQ/nociceptin (OFQ/N) is the endogenously occurring peptide ligand for the nociceptin opioid receptor (NOP) that produces anxiolytic-like effects in mice and rats. The present study assessed the anxiolytic-like activity of 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510), a novel potent piperidine NOP agonist (EC50 12 nM) that binds with high affinity (...

s | 23 reduction of inflammatory markers. Next PG decreases microglia activation after FCI. Our finding suggests that neuroactive steroids have a relevant role in the prevention of ischemic outcome in immature brain. This study was supported by grants GACR P304/12/G069, P304/14/20613S, P303/12/1464, GAUK project No.165115, TACR-TE01020028 and institutional support RVO: 67985823 and CZ.2.16/3.1....

It is our great honor and pleasure to dedicate this special issue of the Journal Raman Spectroscopy Professor Richard P. Van Duyne (1945–2019). well known for his discovery advancement surface-enhanced scattering (SERS), thereby creating a field research that continues be vibrant over 40 years after its initial discovery. This includes papers cover three main directions related SERS, namely, th...

The microbiological quality and shelf life of enzyme-peeled fresh-cut persimmon slices were evaluated during storage in a high CO2 controlled atmosphere (CA) and active modified atmosphere packaging (MAP) at 10 8C. Microbial counts of the enzymepeeled slices were lower in high CO2 atmospheres (10%, 15%, and 20%) than in air during CA storage for 6 days at 10 8C with the 20% CO2 atmosphere being...

Cooperative banks primarily compete with one another because they target niche markets that large typically ignore. The current study shows in this competitive environment, the connection between financial intermediaries affects operational efficiency of small banks. findings indicate capitalization, diversification strategies, funding costs, liquidity, credit quality, and risk bank neighbors h...