The excited state decay of the hydrocarbon radicals ethyl, C(2)H(5); propargyl, C(3)H(3); and benzyl, C(7)H(7) was investigated by femtosecond time-resolved photoionization. Radicals were generated by flash pyrolysis of n-propyl nitrite, propargyl bromide, and toluene, respectively. It is shown that the 2 (2)A(') (3s) Rydberg state of ethyl excited at 250 nm decays with a time constant of 20 fs...

The Northwest Atlantic marine ecosystem off Newfoundland and Labrador, Canada, has been commercially exploited for centuries. Although periodic declines in various important commercial fish stocks have been observed in this ecosystem, the most drastic changes took place in the early 1990s when the ecosystem structure changed abruptly and has not returned to its previous configuration. In the No...

Proteasomal degradation of p53 is mediated by two alternative pathways that are either dependent or independent of both Mdm2 and ubiquitin. The ubiquitin-independent pathway is regulated by NAD(P)H: quinone oxidoreductase 1 (NQO1) that stabilizes p53. The NQO1 inhibitor dicoumarol induces ubiquitin-independent p53 degradation. We now show that, like dicoumarol, several other coumarin and flavon...

Total control of axial and helical chirality elements of a (2-biphenyl)-substituted tetrahydro[5]helicene quinone and the configurationally stable dihydro[4]helicene analogue was achieved in a dynamic kinetic resolution process of an axially chiral racemic diene promoted by an enantiopure sulfinyl benzoquinone.

A new and easily regenerable NAD(P)H model 9,10-dihydrophenanthridine (DHPD) has been designed for biomimetic asymmetric hydrogenation of imines and aromatic compounds. This reaction features the use of hydrogen gas as terminal reductant for the regeneration of the DHPD under the mild condition. Therefore, the substrate scope is not limited in benzoxazinones; the biomimetic asymmetric hydrogena...

Smad Induced Cardiac Fibroblast Differentiation : Nox-4 Gets − β NAD(P)H Oxidases and TGFPrint ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 2005 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/01.RES.0000190403.87462.bf 2005;97:850-852 Circ Res. http://circres....

To study the capabilities and limitations of Raman optical activity, (-)-(M)σ-[10]helicene and (-)-(M)σ-[4]helicene serve as scaffold molecules on which new chiral centers are introduced by substitution of hydrogen atoms with other functional groups. These functional groups are deuterium atoms, fluorine atoms, and methyl groups. Multiply deuterated species are compared. Then, results of singly ...

A fluorescent probe for fulfilling a lysosome targeting function in hypoxic tumor cells is reported, wherein azoreductase triggers a dramatic fluorescence enhancement and specific imaging of lysosomes in hypoxic cancer cells.

SUMMARY Little is known about the long-term fate of acellular dermal matrices in breast implant surgery. A 12-year follow-up case with tissue analysis of AlloDerm in revision breast reconstruction reveals retention of graft volume and integration with an organized collagen structure, minimal capsule formation, and little or no indication of inflammation.