Transformed cells from 80 to 85% of human cancers display measureable levels of active TERT, the reverse transcriptase subunit of telomerase which is essential for growth and survival of these cells. It is well known that the TERT promoter is transcriptionally silenced in development soon after stem cells loose stemness and differentitae. Although interesting from the point of view of regenerat...

Aging is a progressive process that involves a combination of genetic and acquired factors that ultimately cause loss of tissue homeostasis and death. Among the pathways that modulate aging, NF-кB has been shown to play a central role [1]. Interestingly, the majority of studies examining NF-кB and aging suggest that this transcription factor promotes aging. However, as was shown with the role o...