BACKGROUND Previous study has demonstrated that dyspnea exerts inhibitory influence on pain, and empirical research supports the existence of sex differences in pain. To test the hypothesis that the inhibitory influence of dyspnea on the pain sensation may be less in females than in males, the authors investigated the sex differences in the responses of thermal pain threshold to dyspnea in heal...

This study examined the effect of emotion on opiate withdrawal induced hyperalgesia to determine whether emotional states modulate the magnitude of hyperalgesia. One hundred Hispanic men were recruited into one of three groups: heroin withdrawal, long-term heroin abstinence, and control. Participants were presented with pictures to induce neutral, positive, and negative emotional states. Affect...

Trigeminal neuralgia is a paroxysmal disorder with severely disabling facial pain and thus continues to be a real therapeutic challenge. At present there are few effective drugs for treatment of this pain. The present study was aimed to explore the involvement of BK(Ca) channels and Kv channels in the mechanical allodynia in a rat model of trigeminal neuropathic pain. Here the effectiveness of ...

OBJECTIVE Premenstrual dysphoric disorder (PMDD) is associated with increased pain, but there has been a lack of well-controlled research assessing pain responsivity, sex hormones, and their relationships in this group. This study was designed to address this gap in the literature. MATERIALS AND METHODS Healthy, regularly cycling participants (14 PMDD, 14 non-PMDD) attended pain testing sessi...

Background The aim of this study was to investigate the association between neuroticism, pain catastrophizing, and experimentally induced pain threshold and pain tolerance in a healthy adult sample from two regions of the country of Croatia: the island of Korcula and city of Split. Methods A total of 1,322 participants were enrolled from the Island of Korcula (n = 824) and the city of Split (...

BACKGROUND The effect of acupuncture on sensory perception has never been systematically reviewed; although, studies on acupuncture mechanisms are frequently based on the idea that changes in sensory thresholds reflect its effect on the nervous system. METHODS Pubmed, EMBASE and Scopus were screened for studies investigating the effect of acupuncture on thermal or mechanical detection or pain...

abstract background: the most important part in experiencing and recognizing the threshold of pain is the perception of pain. reflexology is a kind of complementary therapy which is rooted in the beliefs of the community. this study was aimed to determine the effect of reflexology on pain perception aspects in patients with chronic low back pain. materials and methods: this single-blind clinica...

The present study was carried out to evaluate the effect of polyherbal formulation (DiarunPlus) on the blood glucose changes and nociceptive threshold and tolerance on non-diabetic mice (which rendered hyperglycemic with exogenous administration of dextrose). This study was carried in 2 phases, during phase-I, the mice were rendered hyperglycemic by repeated injections of dextrose (2g/kg i.p.) ...

OBJECTIVES The aim of this study is to investigate whether quantitative sensory testing with Von Frey monofilaments (VFMs) can be used for the quantification of allodynia in patients with chronic neuropathic pain, and how the pain threshold of affected skin differs from healthy skin. METHODS Using VFMs, we aimed to determine the pain threshold in 22 patients suffering from allodynia as a cons...