Poly(amidoamine) (PAMAM) dendrimer nanoparticles have been demonstrated to elicit a well defined cytotoxicological response from mammalian cell lines, the response increasing systematically with dendrimer generation and number of surface amino groups. In this work, using generation G4, G5, and G6 dendrimers, this systematic response is furthermore demonstrated for the generation of reactive oxy...

Diffusion rate of dye-labelled PAMAM dendrimers through free-standing silica colloidal crystals was studied as a function of the dendrimer generation and nanopore size to determine the transport selectivity.

Diagnostic techniques based on biomolecules have application potential that can be realized in many fields, such as disease diagnosis, bioprocess imaging, food/beverage industries, and environmental pollutant imaging. Successful surface immobilization of is critical to increasing the stabilization, sensitivity, selectivity used bioassay systems. Nanofibers are good candidates for owing advantag...

Background: Lung cancer is a disease of the respiratory system that gets special attention because World Health Organization (WHO) has reported in 2018, lung was with highest number morbidity and mortality rate world. There are several types cancer, one which adenocarcinoma, accounts for about 40% all cancers. In its management, cells often develop resistance to EGFR TKI drugs while Cisplatin C...

Functionalisation of PAMAM dendrimers with a small number of thiol groups makes them good ligands for CdSe/ZnSe nanoparticles; the particles coated with thiolated dendrimers have good cell permeability and are potent transfection agents.

substrates Michal Borkovec Email. [email protected] July 31, 2012 Direct link www.colloid.ch/dendrimers Since their synthesis by Vögtle and Tomalia in the eighties, dendrimers have developed into an very interesting class of novel polymeric materials. Potential applications include surface patterning, synthesis of nanoparticles, or gene delivery. Our research group was much involved in t...

Polyamidoamine (PAMAM) dendrimers have previously been demonstrated to elicit systematically variable cyto- and eco-toxic responses, promising as the basis for structure-activity relationships governing nanotoxicological responses. In this study, increased production of intracellular reactive oxygen species (ROS), genotoxicity and apoptosis due to in vitro exposure of fish hepatocellular carcin...

Multifunctional cancer therapeutic nanodevices have been designed and synthesized using the poly(amidoamine) (PAMAM) dendrimer as a carrier. Partial acetylation of the generation 5 (G5) PAMAM dendrimer was utilized to neutralize a fraction of the primary amino groups, provide enhanced solubility of the dendrimer during the conjugation reaction of fluorescein isothiocyanate (FITC) (in dimethyl s...

Introduction The desire to controllably tune catalyst properties has generated increased interest in the controlled preparation of supported nanoparticle catalysts. Particle size, composition, and morphology may have substantial influences on catalytic activity and, more importantly, selectivity. However, few preparative routes exist to prepare supported catalysts of welldefined morphologies. S...

Generation 5 ethylenediamine (EDA)-cored poly(amidoamine) (PAMAM) dendrimers (E5, E denotes the EDA core and 5 the generation number) with different degrees of acetylation and carboxylation were synthesized and used as a model system to investigate the effect of charge and the influence of dendrimer surface modifications on electrophoretic mobility (EM) and molecular distribution. The surface-m...