Background : The aim of the current study is to examine the effect of systemically administered BP-Pamidronate, on Orthodontic Tooth Movement (OTM) along with osteoclastic quantification in New Zealand white rabbits. Materials & Methods : Twenty rabbits used in the study, were equally divided into 2 groups ; Group-1 as Control & Group-2 as Experimental. A sentalloy NITI closed coil spring (GAC ...

OBJECTIVES To study the efficacy of pamidronate in children with osteogenesis imperfecta (OI). PATIENTS AND METHODS Twenty-nine patients (median age 8.7 years), were given pamidronate in cyclic infusions of 3 days. Patients received 3-13 cycles (median 6), at a dose of 0.5 mg/kg/day in infants (below 2 years of age) and 1 mg/kg/day in children (2 years and older). The interval time between cy...

Osteogenesis Imperfecta (OI) is a connective tissue disorders. There are several types of OI. OI can be autosomal dominant, some cases can be found in recessive by mosaicism in the parent. The main goal of treatment is to reduce the incidence of fractures, prevent deformities of bones and scoliosis, and improve the functional patient. This is a case of OI given alendronate as an alternative tre...

Bone is a preferred site of metastasis for many solid tumors, and the complications associated with bone metastases can result in significant skeletal morbidity including severe bone pain, pathologic fracture, spinal cord compression, and hypercalcemia of malignancy (HCM). Bisphosphonates are the current standard of care for preventing skeletal complications associated with bone metastases. Cli...

INTRODUCTION Bisphosphonates have anti-inflammatory properties in arthritic conditions. This study was conducted to assess the therapeutic potential of intravenous pamidronate in nonsteroidal anti-inflammatory drug (NSAID) refractory/intolerant cases of ankylosing spondylitis (AS). METHODS A total of 35 NSAID refractory/intolerant AS patients with Bath AS Disease Activity Index (BASDAI) score...

A73-year-old female was admitted to our institution after laboratory results during an outpatient follow-up visit for a longstanding hyperparathyroidism revealed a serum calcium concentration of 14.5 mg/dL. She was diagnosed with primary hyperparathyroidism 8 years prior to current presentation. Throughout this time her serum calcium and intact PTH (iPTH) concentrations ranged from 10.2 to 15.0...