A 70-year-old female patient presented with an eruption consisting of symmetrically distributed erythematous papules around the umbilicus 1 month after the cessation of adalimumab for the treatment of rheumatoid arthritis. Biopsy of a papule showed an interstitial granulomatous infiltrate in the dermis, without deposition of mucin. The lesions cleared only after re-initiation of treatment 2 mon...

The typical MC lesion is an asymptomatic, firm, smooth, round papule with central umbilication (Figure 1). Lesions are usually 3 to 5 mm in diameter and number less than 30, although these parameters often are exceeded in persons with HIV and other immunocompromised conditions. In children, the papules typically are found on the M olluscum contagiosum (MC) and warts are benign epidermal eruptio...

Figures 1. Erythematous and verrucous plaque with scrotal ulceration. A 38-year-old Mexican immigrant with no significant past medical history was admitted to the hospital with a 3-week history of progressive left scrotal lesions that started as a single papule and evolved to become a painful erythematous and verrucous plaque with scrotal ulceration (Figure 1). The patient denied fever, chills,...

Pemetrexed is approved to treat non-small cell lung cancer and has an overall favorable toxicity profile. We describe a 58-year-old man who developped an anaphylactic shock within few minutes from the beginning of pemetrexed perfusion. Pemetrexed was discontinued and the patient's symptoms gradually resolved with administration of symptomatic treatment. Serum tryptase level remained normal and ...

AAOC: acral angioosteoma cutis BMP: bone morphogenic protein PG: pyogenic granuloma VEGF: vascular endothelial growth factor INTRODUCTION Googe et al in 2006 first described 11 cases of acral angioosteoma cutis (AAOC), characterized by benign vascular and osseous lesions on acral skin. Since then, there have been only 3 additional cases reported. This friable erythematous exophytic papule has c...

The authors present a case of a 70-year-old female who abruptly developed deep-seated pustule at both palms and soles. Aspiration content of the papule for gram's stain revealed needle-shaped materials with negative birefringence polarized light examination. Histological examination revealed deposition of amorphous materials surrounded by histiocytes, multinucleated giant cells, and lymphocytes...

SCC: squamous cell carcinoma WD: warty dyskeratoma INTRODUCTION Warty dyskeratoma (WD), also known as isolated Darier disease or focal acantholytic dyskeratosis, is a rare mucocutaneous lesion. It usually presents as a solitary, asymptomatic umbilicated papule, most often in the head and neck region of middleto older-age adults. A slight male predilection has been observed. When it occurs in th...

Anthrax is a disease caused by Bacillus anthracis. The disease affects primarily herbivores including sheep, cattle, horses, and other domestic animals. Humans may rarely be affected. We examined one male and two female patients with a localised itchy erythematous papule of the eyelid. A necrotising ulcer formed in each of the three cases resulting in a black lesion. Scraping in each case showe...

Pyogenic granuloma (PG) is a benign vascular lesion of the skin and mucous membranes, presenting as a solitary, red, pedunculated papule that bleeds easily and which appears to be a reactive vascular proliferation to minor injury. These lesions are more common in children and are mostly seen in exposed sites. Multiple disseminated PG is a rare condition. This report describes an infant with mul...

Folliculosebaceous cystic hamartoma (FSCH) is a rare cutaneous hamartoma composed of dilated folliculosebaceous units and mesenchymal elements. It presents as a papule or nodule usually on the face and scalp, rarely on the genital or trunk area. Histologically, FSCH shares several similar features to sebaceous trichofolliculoma. We report one case of FSCH misdiagnosed as a neurofibroma. He was ...