BACKGROUND In two clinical trials, low-grade fever was observed more frequently after coadministration than after separate administration of two recommended routine pediatric vaccines. Since fever is an important issue with vaccine tolerability, we performed this open-label study on the efficacy and safety of prophylactic use of paracetamol (acetaminophen, Benuron®) in children administered rou...

The ethanol extract of Bacopa monnieri Linn. (Schrophulariaceae) aerial parts (EBM) was investigated for any in vitro and in vivo antioxidant and hepatoprotective effects. EBM was prepared and estimation of total phenolics was carried out. Further, the antioxidant activity of EBM was studied using four in vitro models. The amount of total phenolics was estimated to be 47.7 (g of pyr...

Dipeptide esters of paracetamol were prepared in high yields. These compounds are quantitatively hydrolyzed to paracetamol and corresponding 2,5-diketopiperazines at pH 7.4 and 37 degrees C. The reactivity is increased in sarcosine and proline peptides and decreased by bulky side chains at both the N- and C-terminal residues of the dipeptide carrier. Moreover, dipeptide esters of paracetamol di...

Based on the evidence that the antinociceptive effects of paracetamol (acetaminophen) could be mediated centrally, distribution of the cellular activity of the drug after oral administration was aimed to be determined in mouse. This study comprises four groups of mice which were categorized into saline group, paracetamol group, aspirin group and paracetamol group without hot plate test. First, ...

STUDY OBJECTIVE This randomized, placebo-controlled trial evaluates the analgesic efficacy and safety of intravenous single-dose paracetamol and morphine for the treatment of renal colic. METHODS We conducted a randomized, double-blind, placebo-controlled clinical trial comparing single intravenous doses of paracetamol (1 g), morphine (0.1 mg/kg), and placebo (normal saline solution) for pati...

OBJECTIVES To compare the efficacy and safety of single versus combination non-prescription oral analgesics in community-derived people aged 40 years and older with chronic knee pain. METHODS A randomised, double-blind, four-arm, parallel-group, active controlled trial investigating short-term (day 10) and long-term (week 13) benefits and side-effects of four regimens, each taken three times ...

BACKGROUND Paracetamol overdose causes severe hepatotoxicity that leads to liver failure in both humans and experimental animals. The present study investigates the protective effect of honey against paracetamol-induced hepatotoxicity in Wistar albino rats. We have used silymarin as a standard reference hepatoprotective drug. METHODS Hepatoprotective activity was assessed by measuring biochem...

This study was carried out to investigate the hepatoprotective effect of the aqueous extract of Kohautia grandiflora on paracetamol induced hepatotoxicity in rats. A total of 20 albino rats of the Wister strain weighing 120-180 g were used for the study. The animals were divided into 4 groups of 5-rats each [I-IV]. Groups I, II and III served as the normal, paracetamol and plant extract control...

Paracetamol is commonly used to control mild-to-moderate pain or to reduce opioid exposure as part of multimodal analgesia, and is the only compound recommended to treat fever in neonates. Paracetamol clearance is lower in neonates than in children and adults. After metabolic conversion, paracetamol is subsequently eliminated by the renal route. The main metabolic conversions are conjugation wi...

BACKGROUND Paracetamol poisoning is implicated in about 150-200 poisoning deaths per year in England and Wales. We review previous studies assessing the effectiveness of regulations introduced in 1998 to restrict sales of paracetamol and reduce paracetamol poisoning. METHODS We searched the following electronic databases: MEDLINE, EMBASE, CINHAL, HIMIC, COCH, APC, CENTRAL and DARE. English la...