ParaHydrogen Induced Polarization-Side Arm Hydrogenation (PHIP-SAH) is an inexpensive tool to obtain hyperpolarized pyruvate (and other metabolites) that can be applied in vivo diagnostics, for the investigation of metabolic processes. This method based on hydrogenation, using hydrogen enriched para-isomer, unsaturated substrates, catalyzed, usually, by a homogeneous rhodium(I) complex. In this...

In hyperpolarization experiments using parahydrogen, a partially negative line (PNL) of o-H2 is occasionally spotted in the nuclear magnetic resonance (NMR) spectra. This manifestation two-spin order (TSO) proton spins, appearing transiently molecules freshly derived from p-H2. For TSO to be observable, NMR signal must split into doublet. literature, splitting believed originate slow exchange d...