Abstract Acute paraquat poisoning resulting from multiple organ failure usually has a high mortality rate. Liver and kidney, as the key oranges of detoxification elimination, their injuries may suppress toxin excretion enhance toxicity in other organs worsen prognosis. Therefore, we intended to explore prognostic value liver kidney function parameters, further evaluate correlation with more sta...

The use of fully printed electrochemical devices has gained more attention for the monitoring clinical, food, and environmental analytes due to their low cost, great reproducibility, versatility characteristics, serving as an important technology commercial application. Therefore, a paper-based inkjet-printed system is proposed cost-effective analytical detection tool paraquat. Chromatographic ...

El paraquat es un plaguicida del grupo de los herbicidas asociado a una gran morbimortalidad, luego su ingesta con intención suicida. Dentro las ayudas pronósticas, en el paciente intoxicado por esta sustancia, la literatura internacional considera tomografía tórax y sus hallazgos, sin embargo, Colombia, no hay reportes nivel nacional, ni inclusión este parámetro dentro guías Ministerio Salud. ...

Background: Herbicide is any chemical that regulates growth of a plant which encompasses number xenobiotics varying characteristics, they are used for destruction plants in home, agriculture weeds. Commonly available herbicides paraquat, Glyphosate &Phenoxy acids. Methods: The study focuses on acute ingestion commonly and their clinical, radiological laboratory presentations impact mortalit...

In China, and other Asian countries, numerous patients have succumbed to pulmonary fibrosis induced by paquarat poisoning, but the early pathogenesis remains unclear. In this study the effect of cytokine transforming growth factor (TGF)-β1 was observed in early acute paraquat poisoning and examined the mechanism by which paraquat caused early acute lung injury. It was discovered that the rat se...

Paraquat intoxication is characterized by multi-organ failure, causing substantial mortality and morbidity. Many paraquat patients experience acute kidney injury (AKI), sometimes requiring hemodialysis. We observed 222 paraquat-intoxicated patients between 2000 and 2012, and divided them into AKI (n = 103) and non-AKI (n = 119) groups. The mortality rate was higher for AKI than non-AKI patients...

We report the unexpected result that Escherichia coli isolates containing a multicopy plasmid (pDT1.5) carrying the manganese-superoxide dismutase gene sodA were more sensitive than the wild type to paraquat-mediated growth inhibition. The pDT1.5 locus responsible for the paraquat-sensitive phenotype was delimited to a 0.6-kilobase segment by transposon Tn5 mutagenesis. Moreover, superoxide dis...

The efftct was assessed of paraquat administration on the antioxidative defense mechanism in blood and liver. Ten-week-old senescefice-accelerated miee were fed with either a 209t6 casein diet or the same diet supp]emented with 200 ppm paraquat for 12 weeks. About O.2 m] of bloed withdrawn periodically from the supraorbital yein was assayed for the activities of antioxidatiye enzymes and oxidat...

A 29 year old man was admitted 36 hours after ingesting about 5 g paraquat. His arterial oxygen pressure fell progressively to 3.4 kPa (34 mm Hg), and pulmonary damage induced by paraquat was diagnosed. His condition did not improve after treatment with prednisolone and cyclophosphamide, but after irradiation both lungs cleared and arterial oxygen pressure started to improve. Irradiation of the...

Ingestion of paraquat causes multi-organ failure. Prognosis is best estimated through measurement of blood paraquat concentrations but this facility is not available in most hospitals. We studied the prognostic significance of abnormal pancreatic enzymes for survival. Patients with acute paraquat poisoning were recruited. An extensive series of blood tests including serum amylase were serially ...