We introduce a novel method that provides quantitative lipidomics results from Raman maps in the paraventricular nucleus of thalamus (PVT) region post-traumatic stress disorder (PTSD) rat brains.

The aim of our study was to compare the effects a gold salt (sodium tetrachloroaurate) and nanoparticles colloidal solution on morphofunctional state hypothalamus adrenal glands 6-month-old male rats with obesity, which induced using diet-induced model metabolic disorders. rats, modeled for were divided into three groups that received NaCl solution, 10 days. Rats control group standard diet. Af...

Estrogen receptor (ER)beta is present in hypothalamic and limbic neurons of female rat brains, but little is known about its regulation under physiological conditions. To determine whether ER beta expression varies during physiological conditions in which sex steroid hormone profiles are significantly different, we used in situ hybridization to assess ER beta mRNA expression in the periventricu...

Early-life experience including maternal care profoundly influences hormonal stress responses during adulthood. Daily handling on postnatal day (P) 2-9, eliciting augmented maternal care upon returning pups to their cage, permanently modifies the expression of the stress neuromodulators corticotropin-releasing factor (CRF) and glucocorticoid receptor (GR). We have previously demonstrated reduce...

A hierarchical hormonal cascade along the hypothalamic-pituitary-adrenal axis orchestrates bodily responses to stress. Although corticotropin-releasing hormone (CRH), produced by parvocellular neurons of the hypothalamic paraventricular nucleus (PVN) and released into the portal circulation at the median eminence, is known to prime downstream hormone release, the molecular mechanism regulating ...

One of the characteristics of drug dependence is that a drug has to be administered repeatedly before withdrawal effects can be observed. We have previously shown that withdrawal after 14 days of cocaine treatment produces a supersensitivity of hypothalamic 5-hydroxytryptamine (serotonin) 2A (5-HT2A) receptors, which is accompanied by increases in the levels of G q and G 11 proteins. Unfortunat...

Fibers projecting from several levels of the spinal cord to the diencephalon and telencephalon were labeled anterogradely with Phaseolus vulgaris leucoagglutinin injected iontophoretically. Labeled fibers in the thalamus confirmed projections previously observed. In addition, many labeled fibers were seen in the hypothalamus and in telencephalic areas not generally recognized previously as rece...

Williamson M, Viau V. Selective contributions of the medial preoptic nucleus to testosterone-dependant regulation of the paraventricular nucleus of the hypothalamus and the HPA axis. Am J Physiol Regul Integr Comp Physiol 295: R1020–R1030, 2008. First published August 6, 2008; doi:10.1152/ajpregu.90389.2008.—Previous data have consistently demonstrated an inhibitory effect of androgens on stres...

In the present study, we demonstrated that there is a direct relationship between scratching behaviors induced by itch and functional changes in brain reward system. Using conditional place preference test, rewarding effect was clearly evoked under both acute chronic stimuli. The induction of ΔFosB, member Fos family transcription factors, observed dopamine transporter (DAT)-positive neurons ve...