INTRODUCTION To examine the impact of published randomized controlled trial (RCT) data on referrals for adjuvant radiotherapy (RT) in patients who had high-risk pathologic features after radical prostatectomy (RP). METHODS In this population-based, retrospective Canadian study, all patients who received a diagnosis of prostate adenocarcinoma and underwent RP from 2003-2008 were identified thr...

Background: We report two rare cases of inflammatory cloacogenic polyps of the anorectum. The first case involves a 50 year old white female who presented with chronic diarrhea, prolapse, and rectal bleeding. The second case presents a 67 year old white male who presented with hemorrhoids and rectal bleeding. It is hypothesized that correction of prolapse will resolve the pathologic changes. In...

Background & Aims: Osteosarcoma is one of the most prevalent malignant bone tumors . This study is designed to assess the prognostic effect of pathologic fracture and treatment options on survival of patients with osteosarcoma. Materials & Methods: In this study, prognosis of 106 patients with limb osteosarcoma, which were treated at three  hospitals in Tehran from April to August 2012 ...

BACKGROUND Recent studies have suggested that the presence of a pathological fracture does not impact on oncologic outcomes and the feasibility of limb salvage surgery (LSS) in appropriately selected patients when combined with neoadjuvant chemotherapy. These have largely been single institutional studies with limited numbers. The Eastern Asian Musculoskeletal Oncology Group reviewed the data f...

OBJECTIVE To describe peripapillary detachment in pathologic myopia (PDPM), a newly recognized fundus lesion. DESIGN Retrospective medical record review. METHODS We evaluated a series of myopic eyes that had a yellow-orange elevation of the retina and retinal pigment epithelium at the inferior border of the myopic conus. RESULTS Twenty eyes of 15 patients were identified during a 17-year ...

Long-term outcomes for women with a diagnosis of human epidermal growth factor receptor 2 (HER2)-driven early-stage breast cancer have significantly improved since the advent of HER2-targeted therapy. Although the first studies in the early-stage setting focused on the adjuvant use of trastuzumab plus chemotherapy, clinical trials increasingly are using a neoadjuvant design to evaluate novel HE...

Approximately one quarter of patients with breast cancer demonstrate amplification of the human epidermal receptor type 2 (HER2) gene, the expression of which is associated with a relatively poor prognosis independent of other clinical and pathologic variables. Trastuzumab, a humanized recombinant monoclonal antibody specifically directed against the HER2 receptor, has been shown to be biologic...

The objective of this review is to summarize the surgical options for primary osteoarthritis elbow, reported clinical outcomes, and suggested indications in previous literatures. management elbow arthritis has evolved because an improved understanding pathologic mechanisms manifestations as well development novel techniques devices. Osteocapsular arthroplasty (OCA), debridement, distraction art...