By analogy, if Sam Spicer were concerned with athletes, I think he would be the manager of a baseball team. At first glance, he seems to know who the batters are, where his players should position themselves, and what kind of pitches are needed to do the job. What is unfair is that this reader is a middle linebacker by nature and training. Histochemistry contains both the theoretical and the ap...

INTRODUCTION Centrilobular emphysema (CLE) is recognized as low attenuation areas (LAA) with centrilobular distribution on high-resolution computed tomography. The LAA often exhibit a variety of shape or sharpness of border. This study was performed to elucidate the relationship between morphological features of LAA and pathological findings in CLE. MATERIALS AND METHODS The inflated-fixed lu...

OBJECTIVES This study sought to determine the prevalence of hepatocellular carcinoma and other premalignant lesions in children with hereditary tyrosinemia type 1 who had undergone an orthotopic liver transplant at the Shiraz Transplant Center, in Shiraz, Iran. MATERIALS AND METHODS Between September 2006, and June 2011, thirty-six patients with hereditary tyrosinemia type 1 received a liver ...

A LOCALIZED NARROWING of the IAJL aorta at or distal to the ductus arteriosus (coaretation of the adult type) is one of the most comnlon congenital nmalformations of the great vessels. A narrowing of the aorta proximal to a patent ductus arteriosus (coaretation of the infantile type) is less commoni, while complete interruption of the aorta proximal to the ductus is quite rare, and interruption...

Recently, an unusual subtype of large B-cell lymphoma (LBCL) with distinctive clinicopathologic features has been recognized; it is characterized by involvement of bone marrow with or without liver and/or spleen, but no lymph node or other extranodal sites, usually associated with fever, anemia, and hemophagocytic lymphohistiocytosis (HLH). Because of this distinctive clinical presentation, it ...

A LOCALIZED NARROWING of the IAJL aorta at or distal to the ductus arteriosus (coaretation of the adult type) is one of the most comnlon congenital nmalformations of the great vessels. A narrowing of the aorta proximal to a patent ductus arteriosus (coaretation of the infantile type) is less commoni, while complete interruption of the aorta proximal to the ductus is quite rare, and interruption...

OBJECTIVE Pneumocystis carinii pneumonia is the most common and serious of the pulmonary complications of AIDS. Despite this, many basic aspects in the pathogenesis of HIV-associated P carinii pneumonia are unknown. We therefore undertook a light and electron microscopic study of transbronchial biopsy specimens to compare pathologic features of P carinii pneumonia and other HIV-related lung dis...

A fold that occurs within a joint is referred to as a plica synovialis. Three such plicae are seen with regularity within the human knee joint. These folds are normal structures that represent remnants of mesenchymal tissue and/or septa formed during embryonic development of the knee joint, and can be seen during arthroscopic inspection of the knee joint. Controversy exists within the orthopaed...

Detection and characterization of autoantibodies reacting with self-antigens is generally used in laboratory diagnostics. However, the presence of different autoantibodies in the blood serum doesn’t mean automatically a pathologic condition. Autoantibodies are present both in different diseases as autoimmune diseases, chronic inflammation or infections, and in healthy individuals without any sy...

PURPOSE OF REVIEW This review aims to summarize recent developments in the area of systemic amyloidoses with emphasis on pathologic diagnosis. RECENT FINDINGS In recent years, management of amyloidosis has shifted from a purely supportive approach to quite diverse, radical and aggressive treatments. The central issue is the understanding that treatment of systemic amyloidoses depends on the m...