BACKGROUND AND PURPOSE The boundary between vascular dementia and Alzheimer disease (AD) continues to be unclear. Some posit that gradually progressive vascular dementia, as with small vessel disease, is simply vascular disease plus AD. Because AD presents a characteristic pattern on fluorodeoxyglucose positron emission tomography, we sought to determine whether the fluorodeoxyglucose pattern o...

BACKGROUND AND PURPOSE Subcortical ischemic vascular dementia is associated with cortical hypometabolism and hypoperfusion, and this reduced cortical metabolism or blood flow can be detected with functional imaging such as positron emission tomography. The aim of this study was to characterize, by means of MR imaging and 1H MR spectroscopy, the structural and metabolic brain changes that occur ...

Background: The Montreal Cognitive Assessment (MoCA) has been recommended as a cognitive screening tool for clinical practice and research in Parkinson’s disease (PD), yet no normative data have been published for MoCA in PD without dementia.     Methods: We undertook a pooled secondary analysis of data from two studies (one cross-sectional design and one clinical trial) conducted in the East ...

OBJECTIVE To compare the occurrence of spontaneous cerebral emboli and venous to arterial circulation shunts in patients with Alzheimer's disease or vascular dementia and controls without dementia. DESIGN Cross sectional case-control study. SETTING Secondary care old age psychiatry services, Manchester. PARTICIPANTS 170 patients with dementia (85 with Alzheimer's disease, 85 with vascular...

BACKGROUND AND PURPOSE We sought to determine whether previous or incident dementia increases the risk of mortality after stroke. METHODS We assessed clinical, functional, and cognitive status in 324 consecutive stroke patients who were followed up for 24 months. Prestroke dementia was diagnosed at admission (Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition criteri...

Background: Systemic and local inflammatory responses have been proposed as mechanisms in the initiation and progression of dementia. Several studies described increased levels of proinflammatory cytokines in Alzheimer's disease patients. Acute phase reactants such as CRP have been detected within the neuritic plaques and neurofibrillary tangles in the brains of patients with Alzheimer's diseas...

One of the most devastating nonmotor manifestations of PD is dementia. There are few established predictors of dementia in PD. In numerous cross-sectional studies, patients with rapid eye movement (REM) sleep behavior disorder (RBD) have increased cognitive impairment on neuropsychological testing, but no prospective studies have assessed whether RBD can predict Parkinson's dementia. PD patient...

Purpose: The purpose of this mixed methods study was to explore the caring experiences family caregivers patients with early-onset dementia, and identify characteristics dementia.Methods: A qualitative conducted using Colaizzi‘s phenomenological method service needs ten caregivers. quantitative carried out by secondary data analysis compare differences in disease comorbidities between early lat...

PURPOSE Self-reported data suggest that older adults with dementia are inactive. The purpose of the present study was to objectively assess the physical activity (PA) levels of community-dwelling and institutionalized ambulatory patients with dementia, and to compare with the PA levels of cognitive healthy older adults. METHODS We used actigraphy to assess the PA levels in institutionalized (...