The multi-element probabilistic collocation method (ME-PCM) as a tool for sensitivity analysis of differential equation models as applied to cellular signalling networks is formulated. This method utilises a simple, efficient sampling algorithm to quantify local sensitivities throughout the parameter space. The application of the ME-PCM to a previously published ordinary differential equation m...

The centrosome is an unusual organelle that lacks a surrounding membrane, raising the question of what limits its size and shape. Moreover, while electron microscopy (EM) has provided a detailed view of centriole architecture, there has been limited understanding of how the second major component of centrosomes, the pericentriolar material (PCM), is organized. Here, we summarize exciting recent...

The fuzzy c-means (FCM) has been a well-known algorithm in machine learning/data mining area as a clustering algorithm. It can also be used for image segmentation, but the algorithm is not robust to noise. The possibilistic c-means (PCM) algorithm was proposed to overcome such a problem. However, the performance of PCM is too sensitive to the initialization of cluster centers, and often deterio...

INTRODUCTION Lornoxicam (LORN) a nonsteroidal antiinflammatory drug of oxicam class is marketed in combination with Paracetamol, a common analgesic for acute inflammatory disease of joints. MATERIALS AND METHODS LORN and Paracetamol (PCM) were estimated at 280 nm by densitometry using silica gel 60 F254 as stationary phase and a premix of toluene: chloroform: methanol: formic acid (3:5:1.5:0....

Biological responses due to nutrient deprivation in the nematode Caenorhabditis elegans, including L1 diapause and autophagy during dauer formation, can be mediated through the linked DAF-2/insulin/IGF receptor and target-of-rapamycin (TOR) kinase pathways. Here we discuss how altered insulin/TOR signaling may underlie the previously reported phenotypes of worms with a null mutation in the pcm-...

Three composite phase change materials (PCMs) were prepared by blending butyl stearate, dodecanol and RT20 with an organically modified montmorillonite (MMT), respectively. After the three composite PCMs were characterized by DSC, it was indicated that the RT20/MMT composite PCM was a good candidate for building applications due to its large latent heat, suitable phase change temperature and go...

The use of intensive patient-centered management (PCM) for managed care patients with life-limiting diagnosis and multiple comorbid conditions (“complex patients”) can sharply reduce costs and utilization while increasing patient satisfaction. PCM also improves reported quality of life with no adverse effects on survival, a recent study has shown. “Patient-centered management is an emerging, co...

Oxidized low density lipoprotein (Ox-LDL) is considered to be involved in the atherogenic process. Factors influencing the formation of Ox-LDL are thus of importance. Oxidation of LDL in a cell-free system in the presence of copper ions was significantly increased (up to 60%) by the presence of platelet-conditioned medium, (PCM) obtained from collagen-activated platelets for the duration of the...

OBJECTIVE To evaluate the frequency of the real association between paracoccidioidomycosis (PCM) and tuberculosis (TB) as well as the rate of previous TB misdiagnosis in individuals with PCM among the patients treated in the Pulmonology Division of the State University of Campinas Hospital das Clínicas, Campinas, Brazil. METHODS A retrospective study of 227 adult patients with PCM (chronic fo...

Flexible memory is the fundamental component for data processing, storage, and radio frequency communication in flexible electronic systems. Among several emerging memory technologies, phase-change random-access memory (PRAM) is one of the strongest candidate for next-generation nonvolatile memories due to its remarkable merits of large cycling endurance, high speed, and excellent scalability. ...