BACKGROUND Polycystic ovary syndrome (PCOS) is associated with metabolic disturbances which include impaired insulin signalling and glucose metabolism in ovarian follicles. The oocyte is metabolically dependent upon its follicle environment during development, but it is unclear whether PCOS or polycystic ovarian (PCO) morphology alone affect oocyte metabolism and energy-demanding processes such...

OBJECTIVE To evaluate the effects of the GnRH antagonist cetrorelix on the gonadal axis in patients with polycystic ovary syndrome (PCOS). DESIGN Observational clinical study. SETTING Academic research center. PATIENT(S) Ten patients with PCOS and 10 controls with normal ovulation. INTERVENTION(S) Patients received a daily cetrorelix injection (0.25 mg SC at 9:00 am) for 6 days, startin...

OBJECTIVE Insulin resistance (IR) is frequent in polycystic ovary syndrome (PCOS) and contributes to the increased risk for type 2 diabetes mellitus and cardiovascular disease of this population. Several markers of IR are used but most are expensive or have limited sensitivity and specificity. Preliminary data suggest that the menstrual cycle pattern correlates with IR in PCOS but existing stud...

Introduction: Polycystic ovary syndrome (PCOS) causes endocrine disorders that affect the functioning of reproductive system and body's metabolic system. Bowel movement abdominal pain are common complaints PCOS patients. Few studies have been performed on relationship between irritable bowel (IBS), association two syndromes is unclear.
 Material Method: In study, 72 patients were enrolled ...

STUDY QUESTION Does treatment with the insulin sensitizer metformin modify the levels and activation of proteins related to the expression of the insulin-dependent glucose transporter (GLUT4), such as adenosine monophosphate-activated protein kinase (AMPK) and myocyte enhancer factor 2A (MEF2A), in endometria from hyperinsulinemic hyperandrogenemic polycystic ovary syndrome (PCOS h-Ins) patient...

BACKGROUND Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders found in women of reproductive age. Differences in hormonal and metabolic profiles are observed in groups of patients with normal and elevated BMI. Cause of disturbances observed in the two groups of patients with PCOS is analyzed. The aim of the study is to assess whether psychological parameters of lean ...

Abstract Background Epilepsy comorbidities adversely affect the quality of life patients. Women with epilepsy are at a high risk comorbid endocrine disorders. Among them, polycystic ovary syndrome (PCOS) has threefold higher prevalence in women than healthy and is main cause infertility among Clinically, show heterogeneity susceptibility to PCOS. This may be associated genetic factor. Methods T...

Dyslipidemia is a very common metabolic abnormality in women with polycystic ovary syndrome (PCOS). Insulin resistance is a key pathophysiology of PCOS, thus dyslipidemia in women with PCOS may be consistent with those found in an insulin resistant state. In recent meta-analysis, triglycerides and low-density lipoprotein (LDL) cholesterol levels were 26 mg/dL and 12 mg/dL higher, and high-densi...

BACKGROUND Most women with polycystic ovary syndrome (PCOS) have insulin resistance, hyperinsulinemia, and elevated serum IL-6 levels. These elevated IL-6 levels may have links with insulin resistance and hyperandrogenism. Metformin may have beneficial effects on the chronic low-grade inflammatory background associated with PCOS. METHODS A systematic review was performed via PUBMED, EMBASE, a...

Background We aimed to estimate the glomerular filtration rate (GFR) in women with polycystic ovary syndrome (PCOS) and to determine the relationship between GFR with C-reactive protein (CRP) and uric acid. MaterialsAndMethods In this cross-sectional study, one-hundred and forty PCOS women and 60 healthy subjects were evaluated. The study was carried out at Endocrinology Outpatient Clinic, Erzu...