BACKGROUND & OBJECTIVES Cross-sectional magnetic resonance imaging (MRI) suggests that Parkinson's disease (PD) is associated with changes in cerebral tissue volume, diffusion tensor imaging metrics, and perfusion values. Here, we performed a longitudinal multimodal MRI study--including structural, diffusion tensor imaging (DTI), and perfusion MRI--to investigate progressive brain changes over ...

introduction: neuroinflammation may play as an important risk factor in progressive degeneration of dopaminergic cells. antioxidants have protective effects against free radicalsinduced neural damage in parkinson’s disease (pd). in the present study, we examined the effects of ellagic acid (ea) on locomotion and neuroinflammatory biomarkers in a rat model of pd induced by 6-hydroxidopamine (6-o...

A two-wheeled self-balancing robot with a fuzzy PD control method is described and analyzed as an example of a high-order, multiple-variable, nonlinear, strong-coupling, and unstable system. Based on a system structure model, a kinetic equation is constructed using Newtonian dynamics andmechanics. After a number of simulation experiments, we get the bestQ,R, and state-feedback matrices. Then a ...

In this paper, a Proportional-Derivative and Integral (PD-I) type Fuzzy-Neural Network Controller (FNNC) based on Sugeno fuzzy model is proposed for brushless DC drives to achieve satisfied performance under steady state and transient conditions. The proposed FNNC uses the speed error, change of error and the error integral as inputs. While the PD-FNNC is activated in transient states, the PI-F...

Perseveration in the generation of random motor behavior was examined by means of the Vienna perseverance task in groups of de novo (n = 18) and treated (n = 18) patients with early PD, and in control subjects (n = 18). In comparison with control subjects, both the de novo and treated patients with PD were relatively unable to generate random motor sequences, indicating a decreased ability to s...

Comparing with the serial ones, parallel manipulators have potential advantages in terms of high stiffness, accuracy and speed (Merlet, 2001). Especially the high accuracy and speed performances make the parallel manipulators widely applied to the following fields, like the pick-and-place operation in food, medicine, electronic industry and so on. At present, the key issues are the ways to meet...

In this article, a control strategy approach is proposed for system consisting of quadrotor transporting double pendulum. our case, we attempt to achieve swing free transportation the pendulum, while closely follows specific trajectory. This dynamic highly nonlinear, therefore, fulfillment complex task represents demanding challenge. Moreover, achieving dampening pendulum oscillations following...

We reported previously that Ca2+ depletion of Dictyostelium discoideum cells severely inhibits extracellular cyclic nucleotide phosphodiesterase (PD) synthesis at a post-transcriptional step. In this study, further experiments were performed to learn more about the nature of this phenomenon. Examination of the polysomal distribution of PD transcripts in control cells and in cells depleted of Ca...

BACKGROUND Although glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is prevalent in African Americans, their risk of associated neonatal hyperbilirubinemia has not been prospectively studied. OBJECTIVE To compare hemolysis and the risk of hyperbilirubinemia among African American, G-6-PD-deficient neonates (study group) and G-6-PD-normal control subjects. METHODS Consecutive, healthy,...