Production of type I interferons (IFN-I, mainly IFNalpha and IFNbeta) is a hallmark of innate immune responses to all classes of pathogens. When viral infection spreads to lymphoid organs, the majority of systemic IFN-I is produced by a specialized "interferon-producing cell" (IPC) that has been shown to belong to the lineage of plasmacytoid dendritic cells (pDC). It is unclear whether producti...

Parametric down-conversion (PDC) is one of the most widely used methods to create pure single-photon states for quantum information applications. However, little attention has been paid to higher-order photon components in the PDC process, yet these ultimately limit the prospects of generating single photons of high quality. In this paper we investigate the impact of higher-order photon compone...

RESULTS. The mature T 8 is a 65-amino-acid peptide encoded by the G 8 gene with an acetylated and a farnesylated–methylated Nand C-terminus, respectively. Purified T 3 8 is similar to T 1 1 in that (1) both are heterogeneous, containing methylated and demethylated T subunits; (2) each demethylated dimer migrates faster than its methylated counterpart during native gel electrophoresis, and the m...

Quasi-phase-matching (QPM) has enriched the capacity of parametric down-conversion (PDC) in generating biphotons for many fundamental tests and advanced applications. However, it is not clear how the nonidealities and randomness in the QPM grating of a parametric down-converter may affect the quantum properties of the biphotons. This paper intends to provide insights into the interplay between ...

The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and glucose, which is controlled by the PDC. The PDC converts pyruvate, coenzyme A (CoA), and oxidized nicotinamide adenine dinucleotide (NAD(+)) in...

UNLABELLED Primary biliary cirrhosis (PBC) is characterized by antimitochondrial antibodies (AMAs), directed to the E2 component of the pyruvate dehydrogenase complex (PDC-E2). Notwithstanding the presence of mitochondria in virtually all nucleated cells, the destruction in PBC is limited to small intrahepatic bile ducts. The reasons for this tissue specificity remain unknown, although biliary ...

The peritoneal dialysis catheter (PDC) can be placed either through the laparoscopic technique, percutaneous technique or surgical procedures. utilization of these PDC placement procedures is based on successful and reduced risk development complications. main objective this study was to compare complications associated with vs. open‑surgery procedure.

Multicarrier CDMA (MC-CDMA) has become a promising candidate for future wireless multimedia communications for its robustness to frequency-selective fading and its flexibility in handling multiple data rates. Among different multirate access schemes, multicode MC-CDMA is attractive for its high performance, good flexibility in rate matching, and low complexity. However, its performance is limit...

We present a case of a 71-year-old male Chamorro patient from Guam who presented with progressive supranuclear palsy (PSP)-Richardson's syndrome. Considering his strong family history of parkinsonism and a PSP phenotype, he was clinically diagnosed with Guam parkinsonism-dementia complex (PDC). Magnetic resonance imaging (MRI) of the brain revealed prominent midbrain atrophy with preserved pont...