We adapt the inverse iteration method for symmetric matrices to some nonlinear PDE eigenvalue problems. In particular, for p ∈ (1,∞) and a given domain Ω ⊂ Rn, we analyze a scheme that allows us to approximate the smallest value the ratio ∫ Ω |Dψ| pdx/ ∫ Ω |ψ| pdx can assume for functions ψ that vanish on ∂Ω. The scheme in question also provides a natural way to approximate minimizing ψ. Our an...

Patient-derived xenograft (PDX) models have recently emerged as a highly desirable platform in oncology and are expected to substantially broaden the way in vivo studies are designed and executed and to reshape drug discovery programs. However, acquisition of patient-derived samples, and propagation, annotation and distribution of PDXs are complex processes that require a high degree of coordin...

We previously demonstrated that fetuses from undernourished pregnant rats exhibited increased beta-cell mass and hyperinsulinemia, whereas keeping food restriction until adult age caused reduced beta-cell mass, hypoinsulinemia, and decreased insulin secretion. Because these alterations can be related to insulin availability, we have now investigated early and long-term effects of protein calori...

Therapy for rhabdomyosarcoma (RMS) has generally been limited to combinations of conventional cytotoxic agents similar to regimens originally developed in the late 1960s. Recently, identification of molecular alterations through next-generation sequencing of individual tumor specimens has facilitated the use of more targeted therapeutic approaches for various malignancies. Such targeted therapi...

background: the aim of this study was optimization of the polyfect gene delivery method of pcdna3.1 expression vector transfected with the mouse pdx-1 gene in three different kinds of mesenchymal stem cells and hepa cells as well as comparison of transfection efficiency leading to expression of the mentioned gene in the cell types used. materials and methods: rat bone marrow-derived mesenchymal...

objective: the aim of this study was to evaluate the effect of exendin-4 (ex-4) on differentiation of insulin-producing cells (ipcs) from rat bone marrow-derived mesenchymal stem cells (rat-bm-mscs). materials and methods: in this experimental study, rat-bm-mscs were cultured and the cells characterized by flow cytometry analysis of cell surface markers. rat-bm-mscs were subsequently treated wi...

PURPOSE Within the aim of advancing precision oncology, we have generated a collection of patient-derived xenografts (PDX) characterized at the molecular level, and a preclinical model of colon cancer metastasis to evaluate drug-response and tumor progression. EXPERIMENTAL DESIGN We derived cells from 32 primary colorectal carcinomas and eight liver metastases and generated PDX annotated for ...

We previously demonstrated that fetuses from undernourished pregnant rats exhibited increased beta cell mass and hyperinsulinemia, whereas keeping food restriction until adult age caused reduced beta cell mass, hypoinsulinemia and decreased insulin secretion. As these alterations can be related to insulin availability, we have now investigated early and long-term effects of protein calorie food...