background: kidney transplantation is the best alternative treatment for end-stage renal disease. several studies have been devoted to investigate predisposing factors of graft rejection. however, there is inconsistency between the results. the objective of the present study was to utilize an intuitive and robust approach for variable selection, random survival forests (rsf), and to identify im...

In this review, we identify important challenges facing physicians responsible for renal and cardiac transplantation in children based on a review of the contemporary medical literature. Regarding pediatric renal transplantation, we discuss the challenge of antibody-mediated rejection, focusing on both acute and chronic antibody-mediated rejection. We review new diagnostic approaches to antibod...

Background: Despite the long-standing association of macrophage migration inhibitory factor (MIF) with delayed-type hypersensitivity response, the potential role of MIF in chronic allograft nephropathy is unknown. The association between upregulation of MIF expression, macrophage and T cell infiltration and the severity of chronic allograft nephropathy suggests that MIF may be an important medi...

In 1954 Murray performed the first truly successful pediatric kidney transplant from one homozygous twin to another (Murray et al., 1958). In 1966 Kelly reported a kidney transplantation in a patient with dysfunctional bladder who had undergone ileal segment urinary diversion (Kelly et al., 1966). Until that time, patients with ESRD and untreatable dysfunctional urinary tract were excluded from...

Background: Accurate and rapid assessment of allograft function is essential in renal transplant recipients in order to detect allograft rejection and to monitor drug nephrotoxicity. We aimed to evaluate the usefulness of cystatin C as a marker of kidney allograft function in the early post-transplant period and to compare this value with that of conventional serum creatinine concentration. Met...