Despite the tremendous advances in the treatment of childhood kidney tumors, there remain subsets of pediatric renal tumors that continue to pose a therapeutic challenge,mainlymalignant rhabdoid kidney tumors and nonosseous renal Ewing sarcoma. Children with advanced, metastatic, or relapsed disease have a poor disease-free survival rate. Focal adhesion kinase (FAK) is a nonreceptor tyrosine ki...

PURPOSE Examine a contemporary series of patients with primary pediatric malignant mediastinal tumors and determine epidemiology, histology, treatment, and survival. Patients and Methods. All malignancies diagnosed between January 1, 1973 and December 31, 1995 were analyzed. RESULTS Twenty-two patients, age 18 years or less, with pediatric primary mediastinal malignancies were identified from...

Metastatic spinal tumors are usually quite difficult to treat. In patients with metastatic spinal tumors, conventional radiotherapy fails to relieve pain in 20-30% of cases and open surgery often causes considerable trauma and complications, which delays treatment of the primary disease. Percutaneous vertebroplasty (PVP) is considered to be useful in achieving rapid pain control and preventing ...

Introduction: Due to the effect of radiation on both the tumor and the surrounding normal tissues, the side effects of radiation in normal tissues are expected. One of the important complications in the head and neck radiotherapy is the doses reached to the larynx and spinal cord of patients with non-laryngeal head and neck tumors.   Materials and Methods: ...

Malignancy in children presents the major cause of death due to disease between the ages of 1 and 15 year. Tumors differ from tumors in adult age in their nature, localization and prognosis. The basic challenge of pediatric oncology is adjustment of therapy to the biological nature and stage of malignant process, while not interfering with growth and development of the child. The most frequent ...

introduction: thermal ablation by microwave (mwa) has proven efficacy in treatment of primary and metastatic cancers. soft tissue tumors could be ablated completely using mwa. however, bony tissue metastasis particularly spinal vertebral metastasis ablation has not reported yet. case presentation: a 50 year old male patient with primary diagnosed colon cancer undergone surgical resection of tum...

Although musculoskeletal tumors are the third most common type of tumor in the pediatric population, primary tumors of the spine are rarely encountered. Despite their low incidence, pediatric orthopaedic surgeons must always consider the diagnosis in any evaluation of a child with back pain. Although the vast majority of these tumors are benign, most require surgical intervention to achieve dia...

BACKGROUND Pediatric spinal trauma is rare and challenging entity. Although cervical spine is commonly affected, it is often missed on routine imaging investigations. Therefore better understanding of growing spine and its patho-physiology is crucial. METHODS Articles related to pediatric cervical trauma were searched on Pubmed and other online research data banks. We have summarized unique a...