The first national single-step, full-information (phenotype, pedigree, and marker genotype) genetic evaluation was developed for final score of US Holsteins. Data included final scores recorded from 1955 to 2009 for 6,232,548 Holsteins cows. BovineSNP50 (Illumina, San Diego, CA) genotypes from the Cooperative Dairy DNA Repository (Beltsville, MD) were available for 6,508 bulls. Three analyses u...

The philosophy of time travel has an illustrious pedigree, having seen ground-breaking physical and philosophical treatments in the late 1940s early 1950s from Kurt Gödel [...]

Large population biobanks of unrelated individuals have been highly successful in detecting common genetic variants affecting diseases of public health concern. However, they lack the statistical power to detect more modest gene-gene and gene-environment interaction effects or the effects of rare variants for which related individuals are ideally required. In reality, most large population stud...

OBJECTIVE To develop a population-based proband-oriented pedigree information system that can be easily applied to various diseases in genetic epidemiological studies, making allowance for the capture of theoretical family relationships. DESIGNS AND MEASUREMENTS: A population-based proband-oriented pedigree information system with ties of consanguinity based on both population-based household r...

Variance-component methods are popular and flexible analytic tools for elucidating the genetic mechanisms of complex quantitative traits from pedigree data. However, variance-component methods typically assume that the trait of interest follows a multivariate normal distribution within a pedigree. Studies have shown that violation of this normality assumption can lead to biased parameter estima...

PURPOSE One way of evaluating family history (FH) for classifying BRCA1/2 variants of uncertain clinical significance (VUS) is to assess the "BRCA-ness" of a pedigree by comparing it to reference populations. The aim of this study was to assess if prediction of BRCA pathogenic variant (mutation) status based on pedigree information differed due to changes in FH since intake, both in families wi...

30. SELECTION AND DEVELOPMENT OF PURE LINES 337 Pure Line Selection: Basic Issues . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 293 Multistage Selection: Finney’s Rule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 294 Controlling the Residual Variance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....

The VAAST pipeline is specifically designed to identify disease-associated alleles in next-generation sequencing data. In the protocols presented in this paper, we outline the best practices for variant prioritization using VAAST. Examples and test data are provided for case-control, small pedigree, and large pedigree analyses. These protocols will teach users the fundamentals of VAAST, VAAST 2...

This paper discusses how to use the RFID technology to realize the life-time traceability of animals. In order to record movements of an animal, the authors adapt the electronic pedigree designed for drugs to animals, which acts as standard data elements and is transferred between partners. Then a CIS is proposed based on the methodology which ensures movements of the animal to be recorded corr...

UNLABELLED Two functions for pedigree-drawing available in R (http://www.r-project.org): plot.pedigree in kinship and pedtodot in gap are described. The latter requires graphviz (http://www.graphviz.org). They can produce many pedigree diagrams quickly into a single file, serving as alternatives to programs that only offer interactive use. AVAILABILITY Packages kinship and gap are available f...