I the setting of an infected inflatable penile prosthesis (IPP), removal of the reservoir is a surgical challenge. We describe a novel technique for IPP reservoir removal at the time of IPP explantation utilizing laparoscopic instruments. We present two cases of infected IPPs requiring complete removal of all components of the implant. The corporal cylinders and scrotal pump were removed via a ...

What defines ‘severe’ hypospadias? The authors describe those having ‘proximal division of the corpus spongiosum’, but others might consider penoscrotal to perineal hypospadias the ‘severe’ cases, while another definition in this era of urethral plate-based urethroplasty might be those whose ventral curvature leads to plate transection. Less ambiguous terms are needed for surgeons to clearly co...

Introduction Surgical treatment of congenital megaprepuce is challenging and controversial. We report our 10-year experience treating patients with this deformity using a standardized procedure that has similarities to a technique reported by Smeulders et al. (1). Our postoperative complications and mid-term follow-up cosmetic appearance of the genitalia after reconstruction are reviewed. Mat...

Abstract Objectives Penile implant can be a challenging procedure when cavernosal fibrosis is encountered. In some cases, second incision and more aggressive maneuvers may necessary, such as fibrotic tissue ressection, widening of the corporotomies, grafting in order to close cavernous bodies. Tunneling less invasive technique that allows development space inside body prosthesis. Methods We pre...

Steroidogenic factor 1 (SF1, officially NR5A1) is a nuclear receptor involved in adrenal and gonadal development. NR5A1 mutations have been identified in patients with various forms of 46,XY disorders of sex development (DSD), including complete gonadal dysgenesis with or without adrenal insufficiency, mild testicular dysgenesis with ambiguous external genitalia or female external genitalia wit...

OBJECTIVE We demonstrate an innovative use of a barrier surgical wound retractor/protector system for use in a variety of prosthetic urologic procedures (penile prosthetics, artificial urinary sphincters, male slings). MATERIALS AND METHODS We demonstrate the use of a self-retaining ring wound retractor in a multitude of prosthetic urological procedures: insertion of an inflatable penile pros...

OBJECTIVES To report a novel SOX2 (OMIM 184429) mutation in a Chinese family and to describe its ocular and extraocular clinical features. METHODS Ocular and systemic examinations were performed, and genomic DNA was prepared from peripheral leukocytes. The coding exons and the adjacent intronic sequence of SOX2 were analyzed by cycle sequencing. RESULTS A novel heterozygous c.695C>A (p.Thr2...

Vertebrates have four clusters of Hox genes (HoxA, HoxB, HoxC, and HoxD). A variety of expression and mutation studies indicate that posterior members of the HoxA and HoxD clusters play an important role in vertebrate limb development. In humans, mutations in HOXD13 have been associated with type II syndactyly or synpolydactyly, and, in HOXA13, with hand-foot-genital syndrome. We have investiga...

INTRODUCTION Urethral stricture refers to anterior urethral disease, a scarring process involving the spongy erectile tissue of the corpus spongiosum, also referred to as spongiofibrosis 1 . 80% of strictures that are secondary to instrumentation occur at the membranous urethra. The other 20% generally occur at the penoscrotal junction. A study done by Palminteri et al 2 on 1439 patients with u...

Hypospadias is one of the most common congenital anomalies, the treatment of which is both appealing and challenging for any experienced paediatric urologist. The hypospadiac malformation can be defined as a consequence of a misdevelopment of the urethral spongiosum tissue, with a defect of the ventral aspect of the prepuce and the skin of the distal shaft. Usually, an arrest in the normal embr...